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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $115 | In Stock | |
5 mg | $247 | In Stock | |
10 mg | $413 | In Stock | |
25 mg | $692 | In Stock | |
50 mg | $985 | In Stock | |
100 mg | $1,330 | In Stock | |
500 mg | $2,660 | In Stock | |
1 mL x 10 mM (in DMSO) | $272 | In Stock |
Description | H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity. |
In vitro | H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays. The half-life of H3B-120 is only 40 min. H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase). |
Molecular Weight | 372.48 |
Formula | C19H24N4O2S |
Cas No. | 2194903-42-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 35 mg/mL (93.96 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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