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ICA
Catalog No. T15546Cas No. 3374-88-7
Alias N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine
ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).
ICA
Catalog No. T15546Alias N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamineCas No. 3374-88-7
ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $147 | In Stock | |
| 5 mg | $297 | In Stock | |
| 10 mg | $446 | In Stock | |
| 25 mg | $719 | In Stock | |
| 50 mg | $993 | In Stock | |
| 100 mg | $1,390 | In Stock | |
| 500 mg | $2,780 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $416 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM). |
| Targets&IC50 | Leishmania tropica:2.1 μM |
| In vitro | ICA prevents electrically induced runs of atrial fibrillation in the isolated right atrium and induces atrial postrepolarization refractoriness and depolarizes resting membrane potential. SK channel inhibition by ICA (10-30 μM) demonstrates prominent depression of other sodium channel-dependent parameters, at increased pacing frequencies. The SK channel inhibitor ICA shows antiarrhythmic effects. ICA at 1 to 10 μM displays conduction velocity[2]. |
| Alias | N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine |
| Molecular Weight | 254.31 |
| Formula | C13H10N4S |
| Cas No. | 3374-88-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (235.93 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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