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Icenticaftor

🥰Excellent
Catalog No. T9499Cas No. 1334546-77-8
Alias QBW251

Icenticaftor (QBW251) is an orally active potentiator of the CFTR channel.

Icenticaftor

Icenticaftor

🥰Excellent
Purity: 98.39%
Catalog No. T9499Alias QBW251Cas No. 1334546-77-8
Icenticaftor (QBW251) is an orally active potentiator of the CFTR channel.
Pack SizePriceAvailabilityQuantity
1 mg$163In Stock
5 mg$347In Stock
10 mg$521In Stock
25 mg$833In Stock
50 mg$1,170In Stock
100 mg$1,660In Stock
200 mg$2,250In Stock
1 mL x 10 mM (in DMSO)$275In Stock
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Purity:98.39%
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Product Introduction

Bioactivity
Description
Icenticaftor (QBW251) is an orally active potentiator of the CFTR channel.
Targets&IC50
CFTR (G551D):497 nM(EC50), F508del CFTR:79 nM(EC50)
AliasQBW251
Chemical Properties
Molecular Weight361.24
FormulaC12H13F6N3O3
Cas No.1334546-77-8
SmilesCOc1nc(C(=O)NC[C@](C)(O)C(F)(F)F)c(N)cc1C(F)(F)F
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 150 mg/mL (415.24 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7682 mL13.8412 mL27.6824 mL138.4121 mL
5 mM0.5536 mL2.7682 mL5.5365 mL27.6824 mL
10 mM0.2768 mL1.3841 mL2.7682 mL13.8412 mL
20 mM0.1384 mL0.6921 mL1.3841 mL6.9206 mL
50 mM0.0554 mL0.2768 mL0.5536 mL2.7682 mL
100 mM0.0277 mL0.1384 mL0.2768 mL1.3841 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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