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Imipramine

Imipramine
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Purity:99.4%
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Imipramine

Catalog No. T20025Cas No. 50-49-7
Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy.
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Pack SizePriceAvailabilityQuantity
5 mg$52In Stock
10 mg$85In Stock
25 mg$172In Stock
50 mg$268In Stock
100 mg$428In Stock
500 mg$968In Stock
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Product Introduction

Bioactivity
Description
Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy.
In vitro
In DLD-1, HCT-116, and SW-480 cell lines, Imipramine (0.5-300 μM; 3 days) inhibited cell viability, with HCT-116 being more sensitive to it compared to DLD-1 and SW-480[1].
In vivo
In male C57BL/6 mice (6-8 weeks old) exposed to repeated social defeat (RSD) and home cage control (HCC), Imipramine (20 mg/kg or 15 mg/kg; administered intraperitoneally or orally, daily for 24 days) reversed RSD-induced social avoidance behavior, significantly increasing interaction time, and significantly decreased stress-induced mRNA levels for IL-6 in brain microglia[4].
AliasHSDB 3100, Melipramine, HSDB3100, Dimipressin, HSDB-3100
Chemical Properties
Molecular Weight280.41
FormulaC19H24N2
Cas No.50-49-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 100 mg/mL (356.62 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5662 mL17.8310 mL35.6621 mL178.3103 mL
5 mM0.7132 mL3.5662 mL7.1324 mL35.6621 mL
10 mM0.3566 mL1.7831 mL3.5662 mL17.8310 mL
20 mM0.1783 mL0.8916 mL1.7831 mL8.9155 mL
50 mM0.0713 mL0.3566 mL0.7132 mL3.5662 mL
100 mM0.0357 mL0.1783 mL0.3566 mL1.7831 mL

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