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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $35 | In Stock | |
5 mg | $82 | In Stock | |
10 mg | $147 | In Stock | |
25 mg | $297 | In Stock | |
50 mg | $537 | In Stock | |
100 mg | $778 | In Stock | |
500 mg | $1,590 | In Stock | |
1 mL x 10 mM (in DMSO) | $90 | In Stock |
Description | IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4. |
In vitro | AMD11070 shows antagonistic activity as it dose-dependently inhibits the CXCL12-induced intracellular calcium flux This calcium flux is inhibited by IT1t dihydrochloride with an IC50 of 23.1[1]. |
In vivo | IT1t dihydrochloride reduces the formation of early metastases of TNBC in a zebrafish xenograft model. After CXCR4 silencing, tumor cell invasion at metastatic sites was effectively reduced [3]. |
Molecular Weight | 479.57 |
Formula | C21H36Cl2N4S2 |
Cas No. | 1092776-63-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 27mg/mL (56.3mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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