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IT1t dihydrochloride
🥰Excellent
Catalog No. T11693LCas No. 1092776-63-0
IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.
IT1t dihydrochloride
🥰Excellent
Purity: 98.03%
Catalog No. T11693LCas No. 1092776-63-0
IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $35 | In Stock | |
| 5 mg | $82 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $297 | In Stock | |
| 50 mg | $537 | In Stock | |
| 100 mg | $778 | In Stock | |
| 500 mg | $1,590 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $90 | In Stock |
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Purity:98.03%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4. |
| Targets&IC50 | HIV-1 (X4):14.2 nM (in MT-4 cells), HIV-1 (X4):19 nM (in PBMCs), CXCL12-CXCR4:2.1 nM |
| In vitro | AMD11070 shows antagonistic activity as it dose-dependently inhibits the CXCL12-induced intracellular calcium flux This calcium flux is inhibited by IT1t dihydrochloride with an IC50 of 23.1[1]. |
| In vivo | IT1t dihydrochloride reduces the formation of early metastases of TNBC in a zebrafish xenograft model. After CXCR4 silencing, tumor cell invasion at metastatic sites was effectively reduced [3]. |
| Molecular Weight | 479.57 |
| Formula | C21H36Cl2N4S2 |
| Cas No. | 1092776-63-0 |
| Smiles | Cl.Cl.CC1(C)CN2C(CS\C(NC3CCCCC3)=N/C3CCCCC3)=CSC2=N1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 27 mg/mL (56.3 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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