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L-Hyoscyamine
Catalog No. T0962Cas No. 101-31-5
Alias Hyoscyamine, Daturine
L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. Hyoscyamine is a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.
L-Hyoscyamine
Catalog No. T0962Alias Hyoscyamine, DaturineCas No. 101-31-5
L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. Hyoscyamine is a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $36 | In Stock | |
| 100 mg | $48 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.12%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. Hyoscyamine is a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility. |
| Targets&IC50 | AChR:7.5 nM |
| In vitro | In vivo studies with conscious rats demonstrated that L-hyoscyamine (20 mg/kg) extended the cyclic period of migrating myoelectric complexes from 17.6 minutes to 29.0 minutes. |
| In vivo | In CHO cells, L-hyoscyamine inhibits excitant-induced cAMP production (EC50: 7.8 nM). In murine cardiac (atrial and ventricular) membranes, S-(-)-hyoscyamine enhances cyclic AMP synthesis stimulated by pilocarpine by 24%. R-(+)-hyoscyamine competes with [3H]NMS for binding to muscarinic acetylcholine receptor subtypes (m1-m5), with pKi values of 8.67, 8.51, 7.46, 8.56, and 8.53, respectively. L-hyoscyamine increases the TPase activity turnover rate from 0.19/min to 2.11/min in steady-state kinetic measurements. |
| Alias | Hyoscyamine, Daturine |
| Molecular Weight | 289.37 |
| Formula | C17H23NO3 |
| Cas No. | 101-31-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 55 mg/mL (190.07 mM), Sonication is recommended.  Ethanol: 54 mg/mL (186.6 mM) | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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