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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $36 | In Stock | |
100 mg | $48 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. Hyoscyamine is a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility. |
Targets&IC50 | AChR:7.5 nM |
In vitro | In vivo studies with conscious rats demonstrated that L-hyoscyamine (20 mg/kg) extended the cyclic period of migrating myoelectric complexes from 17.6 minutes to 29.0 minutes. |
In vivo | In CHO cells, L-hyoscyamine inhibits excitant-induced cAMP production (EC50: 7.8 nM). In murine cardiac (atrial and ventricular) membranes, S-(-)-hyoscyamine enhances cyclic AMP synthesis stimulated by pilocarpine by 24%. R-(+)-hyoscyamine competes with [3H]NMS for binding to muscarinic acetylcholine receptor subtypes (m1-m5), with pKi values of 8.67, 8.51, 7.46, 8.56, and 8.53, respectively. L-hyoscyamine increases the TPase activity turnover rate from 0.19/min to 2.11/min in steady-state kinetic measurements. |
Alias | Daturine, Hyoscyamine |
Molecular Weight | 289.37 |
Formula | C17H23NO3 |
Cas No. | 101-31-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (190.07 mM), Sonication is recommended. ![]() H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 54 mg/mL (186.6 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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