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Levodropropizine

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Purity:100%

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COA HPLC HNMR

Levodropropizine

Catalog No. T0217Cas No. 99291-25-5

Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.

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Pack Size	Price	Availability	Quantity
1 g	$42	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.
In vitro	Research indicates that Levodropropizine effectively suppresses cough in anesthetized guinea pigs and rabbits. Intravenous administration of Levodropizine in these animals, during mechanically and electrically induced coughs, shows an activity ranging from one-tenth to one-twentieth of codeine, similar to hydroxyzine. Oral Levodropizine treatment for cough induced by irritant aerosols has effects comparable to hydroxyzine and codeine. An intravenous dose of 15 mg/kg Levodropropizine reduces the duration of asphyxiation and the C-fiber response to phenylbiguanide. Additionally, Levodropropizine dose-dependently decreases capsaicin-induced Evans blue dye extravasation in rat airways.
In vivo	Levodropropizine exhibits affinity for both H1 histamine and α-adrenergic receptors.
Alias	(S)-(-)-Dropropizine, DF-526

Chemical Properties

Molecular Weight	236.31
Formula	C13H20N2O2
Cas No.	99291-25-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 44 mg/mL (186.2 mM)

H2O: 12 mg/mL (50.8 mM)

DMSO: 55 mg/mL (232.75 mM)

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2317 mL	21.1586 mL	42.3173 mL	211.5865 mL
5 mM	0.8463 mL	4.2317 mL	8.4635 mL	42.3173 mL
10 mM	0.4232 mL	2.1159 mL	4.2317 mL	21.1586 mL
20 mM	0.2116 mL	1.0579 mL	2.1159 mL	10.5793 mL
50 mM	0.0846 mL	0.4232 mL	0.8463 mL	4.2317 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0423 mL	0.2116 mL	0.4232 mL	2.1159 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc