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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 g | $42 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug. |
In vitro | Research indicates that Levodropropizine effectively suppresses cough in anesthetized guinea pigs and rabbits. Intravenous administration of Levodropizine in these animals, during mechanically and electrically induced coughs, shows an activity ranging from one-tenth to one-twentieth of codeine, similar to hydroxyzine. Oral Levodropizine treatment for cough induced by irritant aerosols has effects comparable to hydroxyzine and codeine. An intravenous dose of 15 mg/kg Levodropropizine reduces the duration of asphyxiation and the C-fiber response to phenylbiguanide. Additionally, Levodropropizine dose-dependently decreases capsaicin-induced Evans blue dye extravasation in rat airways. |
In vivo | Levodropropizine exhibits affinity for both H1 histamine and α-adrenergic receptors. |
Alias | (S)-(-)-Dropropizine, DF-526 |
Molecular Weight | 236.31 |
Formula | C13H20N2O2 |
Cas No. | 99291-25-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 44 mg/mL (186.2 mM) H2O: 12 mg/mL (50.8 mM) DMSO: 55 mg/mL (232.75 mM) ![]() | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
Ethanol/DMSO
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