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Lofexidine

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Purity:99.08%

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COA HNMR HPLC

Lofexidine

Catalog No. T7160Cas No. 31036-80-3

Lofexidine is a selective α2-receptor agonist, Lofexidine reduces narcotic withdrawal symptoms.

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Pack Size	Price	Availability
5 mg	$30	In Stock
50 mg	$85	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Related Compound Libraries of "Lofexidine"

Product Introduction

Bioactivity

Description	Lofexidine is a selective α2-receptor agonist, Lofexidine reduces narcotic withdrawal symptoms.
In vivo	Lofexidine significantly decreased SOWS scores compared to placebo and demonstrated better retention rates in participants undergoing opioid withdrawal. Lofexidine potentially offers a useful non-opioid alternative to treat opioid withdrawal symptoms[1].
Animal Research	8-day, randomized, double-blind, placebo-controlled, parallel-group study in 264 patients dependent on short-acting opioids evaluated the efficacy of lofexidine hydrochloride in reducing withdrawal symptoms in patients undergoing opioid withdrawal.?The primary efficacy measures were SOWS-Gossop on Day 3 and time-to-dropout.?Secondary endpoints included the proportion of participants who were completers;?area under the 5-day SOWS-Gossop - time curve (i.e., AUC1-5), and daily mean SOWS-Gossop, OOWS-Handelsman, MCGI (subject and rater), and VAS-E scores.?Participants received lofexidine HCl 3.2mg daily in four divided doses or matching placebo on Days 1-5, followed by 2days of placebo[1].

Chemical Properties

Molecular Weight	259.13
Formula	C11H12Cl2N2O
Cas No.	31036-80-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62.5 mg/mL (241.19 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8591 mL	19.2953 mL	38.5907 mL	192.9533 mL
5 mM	0.7718 mL	3.8591 mL	7.7181 mL	38.5907 mL
10 mM	0.3859 mL	1.9295 mL	3.8591 mL	19.2953 mL
20 mM	0.1930 mL	0.9648 mL	1.9295 mL	9.6477 mL
50 mM	0.0772 mL	0.3859 mL	0.7718 mL	3.8591 mL
100 mM	0.0386 mL	0.1930 mL	0.3859 mL	1.9295 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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