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Losmapimod

🥰Excellent
Catalog No. T2277Cas No. 585543-15-3
Alias SB856553, GW856553X, GW856553, GSK-AHAB

Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).

Losmapimod

Losmapimod

🥰Excellent
Purity: 99.05%
Catalog No. T2277Alias SB856553, GW856553X, GW856553, GSK-AHABCas No. 585543-15-3
Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).
Pack SizePriceAvailabilityQuantity
2 mg28 €In Stock
5 mg45 €In Stock
10 mg67 €In Stock
25 mg134 €In Stock
50 mg225 €In Stock
100 mg406 €In Stock
500 mg920 €In Stock
1 mL x 10 mM (in DMSO)47 €In Stock
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Purity:99.05%
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Product Introduction

Bioactivity
Description
Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).
Targets&IC50
p38α:8.1(pKi), p38β:7.6(pKi)
Kinase Assay
DNA binding assays: All reactions are performed in black non-binding polystyrene 384-well plates with reaction volumes of 30–100 μL. Purified DNA strand exchange proteins and chemical compounds are pre-incubated at room temperature for 5 minutes; they are then further incubated at 37°C for 30 min with 100 nM of ssDNA substrate, consisting of a 45-mer poly-dT tagged with Alexa 488 at the 5' terminus (synthesized and purified by Integrated DNA Technologies). Reactions are performed in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.25 μM BSA, 2% glycerol, 30 mM NaCl, 4% DMSO and 2 mM ATP. Some conditions included DTT or TCEP (tris(2-carboxyethyl)phosphine) as indicated. DNA binding is measured as a function of fluorescence polarization (FP) with a Safire2 plate reader, using the following settings: excitation 470±5 nM, emission 530±5 nM, 10 reads/well, Z height and G factor auto-calibrated from control wells. Displayed error bars represent standard deviation. For experiments involving a titration of protein concentrations, data are fit to an equation that accounts for the cooperative nature by which recombinase proteins bind DNA. For experiments involving a titration of RI-1, protein concentrations are selected to give an ~80% saturation of the FP signal in the absence of RI-1.
AliasSB856553, GW856553X, GW856553, GSK-AHAB
Chemical Properties
Molecular Weight383.46
FormulaC22H26FN3O2
Cas No.585543-15-3
SmilesCC=1C(=CC(C(NC2CC2)=O)=CC1F)C3=CC=C(C(NCC(C)(C)C)=O)C=N3
Relative Density.1.21 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 39 mg/mL (101.7 mM)
DMSO: 18.33 mg/mL (47.81 mM), Sonication is recommended.
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.6078 mL13.0392 mL26.0783 mL130.3917 mL
5 mM0.5216 mL2.6078 mL5.2157 mL26.0783 mL
10 mM0.2608 mL1.3039 mL2.6078 mL13.0392 mL
20 mM0.1304 mL0.6520 mL1.3039 mL6.5196 mL
Ethanol
1mg5mg10mg50mg
50 mM0.0522 mL0.2608 mL0.5216 mL2.6078 mL
100 mM0.0261 mL0.1304 mL0.2608 mL1.3039 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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