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Lucanthone
🥰Excellent
Catalog No. T4569Cas No. 479-50-5
Alias Lucantona, Lucanthonum
Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).
Lucanthone
🥰Excellent
Purity: 99.76%
Catalog No. T4569Alias Lucantona, LucanthonumCas No. 479-50-5
Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $51 | In Stock | |
| 2 mg | $73 | In Stock | |
| 5 mg | $128 | In Stock | |
| 10 mg | $198 | In Stock | |
| 25 mg | $422 | In Stock | |
| 50 mg | $623 | In Stock | |
| 100 mg | $882 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $143 | In Stock |
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Purity:99.76%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1). |
| In vitro | Lucanthone, an innovative autophagy inhibitor, induces apoptosis through cathepsin D activation and has been evaluated for its anticancer efficacy via MTT assay. Demonstrating a consistent reduction in viability across seven breast cancer cell lines, Lucanthone surpasses Chloroquine (CQ) in potency, evidenced by a significantly lower mean IC50 of 7.2 μM compared to 66 μM for CQ. Further validation through ATPlite assay and trypan blue exclusion in two representative cell lines (MDA-MB-231 and BT-20) confirms these findings. |
| Cell Research | Cell viability is assessed by MTT assay. Cells are seeded into 96-well microculture plates at 10,000 cells per well and allowed to attach for 24 h. Cells are then treated with Lucanthone (0, 0.5, 1, 5, 10, 20 and 40 μM), Chloroquine, Vorinostat, or combinations for 72 h. Following drug treatment, MTT is added and cell viability is quantified using a BioTek microplate reader. Effects on cell viability are also determined by measuring ATP levels using the ATPlite assay system and by trypan blue exclusion. Pro-apoptotic effects following in vitro drug exposure are quantified by propidium iodide (PI) staining and fluorescence-activated cell sorting (FACS) analysis of sub-G0/G1 DNA content[2] |
| Alias | Lucantona, Lucanthonum |
| Molecular Weight | 340.48 |
| Formula | C20H24N2OS |
| Cas No. | 479-50-5 |
| Smiles | CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12 |
| Relative Density. | 1.184g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (176.22 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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