Shopping Cart
- Remove All
Your shopping cart is currently empty
Mizoribine
🥰Excellent
Catalog No. T1188Cas No. 50924-49-7
Alias NSC 289637, HE 69, Bredinin
Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.
Mizoribine
🥰Excellent
Purity: 99.98%
Catalog No. T1188Alias NSC 289637, HE 69, BredininCas No. 50924-49-7
Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $45 | In Stock | |
| 25 mg | $61 | In Stock | |
| 50 mg | $97 | In Stock | |
| 100 mg | $166 | In Stock | |
| 200 mg | $216 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Mizoribine"
Hydroxychloroquine
Cited
2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol
T9287118-42-3
Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it's also being studied as an experimental treatment for COVID-19.
- $30
Size
QTY
CitedKojic acid
T5889501-30-4
Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC50 value of 30.6 μM for mushroom tyrosinase.
- $39
Size
QTY
Oxyresveratrol
trans-Oxyresveratrol, Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene
T3S106829700-22-9
1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxidant activity, can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2.
- $31
Size
QTY
Methyl 2-amino-5-bromobenzoate
Methyl 5-Bromoanthranilate
T7822652727-57-8
Methyl 2-amino-5-bromobenzoate (Methyl 5-Bromoanthranilate) is a hepatitis C virus NS5b RNA polymerase inhibitor with antimicrobial activity that inhibits Pseudomonas aeruginosa infections and is involved in the production of many virulence factors and biofilm formation.
- $30
Size
QTY
Methyl cinnamate
T5552103-26-4
Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.
- $44
Size
QTY
Dexamethasone
Cited
Prednisolone F, NSC 34521, MK 125, Hexadecadrol
T107650-02-2
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and IL receptor modulator with anti-inflammatory and immunosuppressive properties that induces autophagy and inhibits LPS-induced inflammatory responses in macrophages.
ADC CytotoxinAntibacterialAntibioticAutophagyComplement SystemGlucocorticoid ReceptorIL ReceptorMitophagySARS-CoV
- $29
Size
QTY
CitedArtemisinin Cited
Qinghaosu,Artemisinine, Qinghaosu, NSC 369397, Artemisinine
T039263968-64-9
Artemisinin (Qinghaosu) is a natural product, a sesquiterpene lactone, derived from Artemisia annua. Artemisinin has anti-malarial activity, as well as neuroprotective and anti-tumor activity.
- $30
Size
QTY
CitedChloroquine phosphate Cited
Chloroquine diphosphate, Chingamin phosphate, Aralen phosphate
T019450-63-5
Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
- $42
Size
QTY
CitedRibavirin Cited
Tribavirin, RTCA, NSC-163039, ICN-1229
T068436791-04-5
Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
- $39
Size
QTY
CitedSilymarin
Silybin B
T667065666-07-1
Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.
- $42
Size
QTY
2-Ketoglutaric acid
T5980328-50-7
2-Ketoglutaric acid is a key molecule in the tricarboxylic acid cycle,is also connected to glutamic acid and glutamine metabolisms through the transamination reactions.
- $42
Size
QTY
Remdesivir Cited
GS-5734
T77661809249-37-3
Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viruses, and is potentially therapeutic against COVID-19.
- $122
Size
QTY
CitedSelect Batch
Purity:99.98%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. |
| Targets&IC50 | Immunosuppressive:100 μM |
| In vitro | Mizoribine selectively inhibits guanine ribonucleotide synthesis in purified T-cells, while the mechanism of 6-thioguanine (6MP) appears to rely more on the depletion of adenine ribonucleotides. In a dose-dependent manner, Mizoribine at 1-50 mg/mL suppresses T-cell proliferation induced by all tested stimuli by 10-100%. This suppression is reversible with the addition of guanosine to replenish the guanine nucleotide pool when 50 mM is incorporated. Furthermore, Mizoribine impedes HCV RNA replication with an IC50 of 100 μM and causes a reduction in intracellular GTP levels, with GTP supplementation reversing its antiproliferative effect. |
| In vivo | Administration of 5 or 10 mg/kg Mizoribine resulted in increased expression of MCP-1, OPN, and TGF-β1 mRNA in untreated OLETF rats. Simultaneously, this dose of Mizoribine inhibited urinary albumin excretion and attenuated the progression of glomerulosclerosis, renal interstitial fibrosis, and macrophage infiltration in the rat kidneys. |
| Alias | NSC 289637, HE 69, Bredinin |
| Molecular Weight | 259.22 |
| Formula | C9H13N3O6 |
| Cas No. | 50924-49-7 |
| Smiles | O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(O)=C(C(N)=O)N=C2 |
| Relative Density. | 1.4155 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (231.46 mM)  Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: 47 mg/mL (181.3 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Mizoribine | purchase Mizoribine | Mizoribine cost | order Mizoribine | Mizoribine chemical structure | Mizoribine in vivo | Mizoribine in vitro | Mizoribine formula | Mizoribine molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.