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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $55 | In Stock | |
2 mg | $81 | In Stock | |
5 mg | $133 | In Stock | |
10 mg | $226 | In Stock | |
25 mg | $455 | In Stock | |
50 mg | $677 | In Stock | |
100 mg | $963 | In Stock | |
1 mL x 10 mM (in DMSO) | $145 | In Stock |
Description | MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. |
Targets&IC50 | PI4K (P. falciparum):(Kdapp) 0.3 μM |
In vitro | MMV390048 against the intraerythrocytic life cycle stages of P. falciparum displayed a steep inhibition curve (IC50: IC90 values of 28 and 40 nM, respectively). |
Molecular Weight | 393.38 |
Formula | C18H14F3N3O2S |
Cas No. | 1314883-11-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (228.79 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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