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MRT-81
🥰Excellent
Catalog No. T9532Cas No. 1263132-08-6
MRT-81 is a potent antagonist of human and rodent smoothened receptors that inhibits hedgehog activity with an IC50 value of 41 nM in Shh-light2 cells.It is used in the study of cancer.
MRT-81
🥰Excellent
Purity: 98.31%
Catalog No. T9532Cas No. 1263132-08-6
MRT-81 is a potent antagonist of human and rodent smoothened receptors that inhibits hedgehog activity with an IC50 value of 41 nM in Shh-light2 cells.It is used in the study of cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $68 | In Stock | |
| 5 mg | $163 | In Stock | |
| 10 mg | $247 | In Stock | |
| 25 mg | $446 | In Stock | |
| 50 mg | $645 | In Stock | |
| 100 mg | $886 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $196 | In Stock |
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Purity:98.31%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MRT-81 is a potent antagonist of human and rodent smoothened receptors that inhibits hedgehog activity with an IC50 value of 41 nM in Shh-light2 cells.It is used in the study of cancer. |
| Targets&IC50 | Smo receptor (Shh-light2 cells):41 nM (IC50) |
| In vitro | MRT-81 inhibits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatase positive osteoblasts induced by the Smo agonist SAG with 0.1 μM, with an IC50 value of 64 nM[1]. |
| Molecular Weight | 555.64 |
| Formula | C31H29N3O5S |
| Cas No. | 1263132-08-6 |
| Smiles | COc1cc(cc(OC)c1OC)C(=O)NC(=S)Nc1ccc(C)c(NC(=O)c2ccc(cc2)-c2ccccc2)c1 |
| Relative Density. | 1.289 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (89.98 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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