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Nemifitide diTFA

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Purity:99.84%

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COA HPLC MS

Nemifitide diTFA

Catalog No. TP1127Cas No. 204992-09-6

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide, a peptide like melanocyte suppressor factor (MIF) that can cross the blood-brain barrier and has potent antidepressant activity.

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Pack Size	Price	Availability	Quantity
1 mg	$84	In Stock

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Product Introduction

Bioactivity

Description	Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide, a peptide like melanocyte suppressor factor (MIF) that can cross the blood-brain barrier and has potent antidepressant activity.
In vitro	Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind to several receptors, including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5, and bombesin, at micromolar concentrations[2].
In vivo	Administered intraperitoneally at a dose of 0.3 mg/kg daily for 14 days, Nemifitide diTFA (INN 00835 diTFA) significantly increases swimming behavior in the FSL rats after just 5 days of treatment, and this effect has a long-lasting duration[2]. Moreover, across a range of doses (0.0125-15.0 mg/kg), Nemifitide diTFA demonstrates a significant increase in swimming behavior in FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses, but not at intermediate (0.4-2.4 mg/kg) doses[3].
Alias	INN 00835 diTFA

Chemical Properties

Molecular Weight	922.8
Formula	C37H45F7N10O10
Cas No.	204992-09-6

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200 mg/mL (216.73 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0837 mL	5.4183 mL	10.8366 mL	54.1829 mL
5 mM	0.2167 mL	1.0837 mL	2.1673 mL	10.8366 mL
10 mM	0.1084 mL	0.5418 mL	1.0837 mL	5.4183 mL
20 mM	0.0542 mL	0.2709 mL	0.5418 mL	2.7091 mL
50 mM	0.0217 mL	0.1084 mL	0.2167 mL	1.0837 mL
100 mM	0.0108 mL	0.0542 mL	0.1084 mL	0.5418 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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