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Niaprazine
🥰Excellent
Catalog No. T36949Cas No. 27367-90-4
Niaprazine is a histamine H1-receptor antagonist exhibiting significant sedative properties.
Niaprazine
🥰Excellent
Purity: 99.5%
Catalog No. T36949Cas No. 27367-90-4
Niaprazine is a histamine H1-receptor antagonist exhibiting significant sedative properties.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $34 | In Stock | |
| 5 mg | $53 | In Stock | |
| 10 mg | $88 | In Stock | |
| 25 mg | $147 | In Stock | |
| 50 mg | $221 | In Stock | |
| 100 mg | $326 | In Stock | |
| 200 mg | $468 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock |
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Purity:99.5%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Niaprazine is a histamine H1-receptor antagonist exhibiting significant sedative properties. |
| Targets&IC50 | 5-HT2:25 nM(Ki), α1-adrenoceptor:77 nM(Ki) |
| In vitro | Niaprazine demonstrates a low affinity for the vesicular monoamine transporter as well as D2, α2, β, H1, and mAch receptors. Notably, the (+)stereoisomer of Niaprazine shows a significantly higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, whereas it is poorly recognized by 5-HT1A and 5-HT1B binding sites[2]. |
| In vivo | Niaprazine (60 mg/kg; i.p.; once) treatment increases rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 minutes post-treatment but reduces them 3-8 hours after treatment. Niaprazine also temporarily depletes rat brain noradrenaline (NA) and dopamine (DA) levels[3]. Animal Model: Male Sprague-Dawley rats (150-200 g)[3]. |
| Molecular Weight | 356.44 |
| Formula | C20H25FN4O |
| Cas No. | 27367-90-4 |
| Smiles | CC(CCN1CCN(CC1)c1ccc(F)cc1)NC(=O)c1cccnc1 |
| Relative Density. | 1.165 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (280.55 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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