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NS9283
Catalog No. T28199Cas No. 913830-15-6
NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $38 | In Stock | |
| 5 mg | $97 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $313 | In Stock | |
| 50 mg | $493 | In Stock | |
| 100 mg | $723 | In Stock | |
| 500 mg | $1,520 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NS9283 is a positive allosteric modulator of α4β2 receptor. |
| In vitro | NS9283 increased the potency of varenicline to activate and desensitize α4β2?nAChRs in vitro without affecting other known targets of varenicline[2]. |
| In vivo | In male and female C57BL/6J mice, NS9283 (10 mg/kg) reduced ethanol intake in a two-bottle choice, intermittent drinking procedure without affecting saccharin intake, ethanol-induced incoordination or ethanol-induced loss of the righting reflex. Subthreshold doses of NS9283 (2.5 mg/kg) plus varenicline (0.1 mg/kg) synergistically reduced ethanol intake in both sexes. Finally, despite having no aversive valence of its own, NS9283 enhanced ethanol-conditioned place aversion[2]. |
| Alias | NS 9283, NS-9283 |
| Molecular Weight | 248.24 |
| Formula | C14H8N4O |
| Cas No. | 913830-15-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
| Solubility Information | DMSO: 3.06 mg/ml (12.31 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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