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NVP-ADW742

Catalog No. T6079Cas No. 475488-23-4
Alias GSK 552602A, ADW742, ADW

NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

NVP-ADW742

NVP-ADW742

Purity: 99.79%
Catalog No. T6079Alias GSK 552602A, ADW742, ADWCas No. 475488-23-4
NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
2 mg$68In Stock
5 mg$107In Stock
10 mg$178In Stock
25 mg$321In Stock
50 mg$591In Stock
100 mg$843In Stock
1 mL x 10 mM (in DMSO)$108In Stock
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Purity:99.79%
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Product Introduction

Bioactivity
Description
NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
Targets&IC50
IGF-1R:0.17 μM
AliasGSK 552602A, ADW742, ADW
Chemical Properties
Molecular Weight453.58
FormulaC28H31N5O
Cas No.475488-23-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 10 mg/mL (22.04 mM), Heating is recommended.
Ethanol: 3 mg/mL (6.61 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.2047 mL11.0234 mL22.0468 mL110.2341 mL
5 mM0.4409 mL2.2047 mL4.4094 mL22.0468 mL
DMSO
1mg5mg10mg50mg
10 mM0.2205 mL1.1023 mL2.2047 mL11.0234 mL
20 mM0.1102 mL0.5512 mL1.1023 mL5.5117 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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