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NVP-TNKS656

NVP-TNKS656
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Purity:99.55%
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NVP-TNKS656

Catalog No. T3261Cas No. 1419949-20-4
NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$38In Stock
2 mg$52In Stock
5 mg$81In Stock
10 mg$131In Stock
25 mg$275In Stock
50 mg$468In Stock
100 mg$686In Stock
1 mL x 10 mM (in DMSO)$89In Stock
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Product Introduction

Bioactivity
Description
NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor.
Targets&IC50
TNKS2:6 nM
In vitro
In vitro, NVP-TNKS656 shows low to moderate microsomal ER values across species and high solubility. [1] In PI3K or AKT inhibitor-resistant cells, NVP-TNKS656 blocks Wnt/β-Catenin pathway and promotes apoptosis. [2]
In vivo
In mice, NVP-TNKS656 displays low clearance and volume of distribution, and exhibits good exposure and moderate oral bioavailability. In MMTV-Wnt1 tumor bearing athymic nude mice, NVP-TNKS656 (350 mg/kg, p.o.) stabilizes Axin1 protein and reduces the Wnt/beta-catenin target gene Axin2 mRNA level by 70-80%. [1] In colorectal cancer PDX models, NVP-TNKS656 reduces nuclear β-catenin, reverts such resistance, and represses tumor growth. [2]
AliasTNKS656
Chemical Properties
Molecular Weight494.58
FormulaC27H34N4O5
Cas No.1419949-20-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 93 mg/mL (188 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 10 mg/mL (20.21 mM), Heating is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.0219 mL10.1096 mL20.2192 mL101.0959 mL
5 mM0.4044 mL2.0219 mL4.0438 mL20.2192 mL
10 mM0.2022 mL1.0110 mL2.0219 mL10.1096 mL
20 mM0.1011 mL0.5055 mL1.0110 mL5.0548 mL
DMSO
1mg5mg10mg50mg
50 mM0.0404 mL0.2022 mL0.4044 mL2.0219 mL
100 mM0.0202 mL0.1011 mL0.2022 mL1.0110 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

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