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Odanacatib

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Purity:98.53%

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COA HNMR HPLC

Odanacatib

Catalog No. T6035Cas No. 603139-19-1

Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.

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Pack Size	Price	Availability
1 mg	$45	In Stock
2 mg	$64	In Stock
5 mg	$107	In Stock
10 mg	$171	In Stock
25 mg	$287	In Stock
50 mg	$432	In Stock
100 mg	$639	In Stock
1 mL x 10 mM (in DMSO)	$121	In Stock

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Product Introduction

Bioactivity

Description	Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
In vitro	In rats, Odanacatib (10 mg/kg) exhibits efficient clearance (Cl: 2 mL kg-1 min-1), low volume of distribution (Vdss: 1.1 L kg-1), a half-life (T1/2) of 6 hours, and oral bioavailability (F) of 8%.
In vivo	Odanacatib exhibits inhibitory activity towards human cathepsin K (IC50=0.2 nM) and rabbit cathepsin K (IC50=1 nM). It also demonstrates effectiveness in human cell assays with an IC50 value of 5 nM.
Alias	MK-0822

Chemical Properties

Molecular Weight	525.56
Formula	C25H27F4N3O3S
Cas No.	603139-19-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (177 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9027 mL	9.5137 mL	19.0273 mL	95.1366 mL
5 mM	0.3805 mL	1.9027 mL	3.8055 mL	19.0273 mL
10 mM	0.1903 mL	0.9514 mL	1.9027 mL	9.5137 mL
20 mM	0.0951 mL	0.4757 mL	0.9514 mL	4.7568 mL
50 mM	0.0381 mL	0.1903 mL	0.3805 mL	1.9027 mL
100 mM	0.0190 mL	0.0951 mL	0.1903 mL	0.9514 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc