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PHA 543613
Catalog No. T23145Cas No. 478149-53-0
PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.
PHA 543613
Catalog No. T23145Cas No. 478149-53-0
PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $46 | In Stock | |
| 5 mg | $109 | In Stock | |
| 10 mg | $178 | In Stock | |
| 25 mg | $397 | In Stock | |
| 50 mg | $678 | In Stock | |
| 100 mg | $995 | In Stock | |
| 500 mg | $2,160 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $107 | In Stock |
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Purity:99.48%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia. |
| Targets&IC50 | α7 nAChR:8.8 nM (Ki) |
| In vivo | In rats, PHA-543613 (0.3 mg/kg) reverses Scopolamine-induced short-term memory deficits[2]. Intraperitoneal injection of PHA-543613 (4 and 12 mg/kg) increases p-Akt and decreases p-GSK-3 and CC3 expressions in the ipsilateral hemisphere. PHA-543613 reduces neuronal cell death in the perihematomal area[3]. |
| Molecular Weight | 271.31 |
| Formula | C15H17N3O2 |
| Cas No. | 478149-53-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 225.0 mg/mL (829.3 mM), Sonication is recommended. H2O: < 30.78 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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