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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $50 | In Stock | |
5 mg | $113 | In Stock | |
10 mg | $213 | In Stock | |
25 mg | $415 | In Stock | |
50 mg | $770 | In Stock | |
100 mg | $1,080 | In Stock | |
500 mg | $2,160 | In Stock |
Description | PNU-282987 free base is a selective and potent α7 nicotinic acetylcholine receptor (nAChR) agonist and 5-HT3 receptor antagonist with anti-inflammatory activity.PNU-282987 free base protects against sepsis-induced acute lung injury in mice, attenuates activation of ILC2s and Streptozotocin-induced airway inflammation.PNU-282987 free base is used in the study of neurological diseases. |
In vitro | PNU-282987 is an agonist of α7 neuronal nicotine receptor ( EC50 = 154 n M ) and an inhibitor of 5-HT3 receptor ( IC50 = 4541 n M )[1]. |
In vivo | In Rats, PNU-282987 free base ( 1,3 mg/kg ; i.v. ) can significantly reversed amphetamine-induced gating deficit[1]. |
Molecular Weight | 264.75 |
Formula | C14H17ClN2O |
Cas No. | 711085-63-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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