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PNU-282987

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Catalog No. T2422Cas No. 123464-89-1

PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).

PNU-282987

PNU-282987

🥰Excellent
Purity: 100%
Catalog No. T2422Cas No. 123464-89-1
PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
Pack SizePriceAvailabilityQuantity
5 mg38 €In Stock
10 mg61 €In Stock
25 mg126 €In Stock
50 mg227 €In Stock
100 mg417 €In Stock
200 mg555 €In Stock
1 mL x 10 mM (in DMSO)67 €In Stock
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Product Introduction

Bioactivity
Description
PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).
Targets&IC50
α7 nAChR (rat):26 nM(Ki)
Kinase Assay
Kinase inhibition assays : Kinase inhibition is measured by the use of radiometric assays conducted by Kinase Profiler service. Briefly, in the presence or absence of SKLB1002, VGFR2 (5–10 mU) is incubated in 25-μL reaction solution containing 8 mmol/L 3-(N-morpholino)propanesulfonic acid (MOPS), pH 7.0, 0.2 mmol/L EDTA, 0.33 mg/mL myelin basic protein, 10 mmol/L Mg acetate, and γ-[33P]ATP. After incubation for 40 minutes at room temperature, the reaction is stopped and 10 μL of the reaction solution is then spotted onto a P30 filtermat and washed 3 times for 5 minutes in 75 mmol/L phosphoric acid and once in methanol prior to scintillation counting.
Chemical Properties
Molecular Weight301.21
FormulaC14H18Cl2N2O
Cas No.123464-89-1
SmilesCl.C1CN2CCC1[C@H](C2)NC(=O)c1ccc(cc1)Cl
Relative Density.1.27g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (166 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3199 mL16.5997 mL33.1994 mL165.9971 mL
5 mM0.6640 mL3.3199 mL6.6399 mL33.1994 mL
10 mM0.3320 mL1.6600 mL3.3199 mL16.5997 mL
20 mM0.1660 mL0.8300 mL1.6600 mL8.2999 mL
50 mM0.0664 mL0.3320 mL0.6640 mL3.3199 mL
100 mM0.0332 mL0.1660 mL0.3320 mL1.6600 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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