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Prochlorperazine Maleate

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Purity:99.99%

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COA HPLC HNMR

Prochlorperazine Maleate

Catalog No. T0385Cas No. 84-02-6

Prochlorperazine Maleate (Capazine) is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS.

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Pack Size	Price	Availability
25 mg	$38	In Stock
50 mg	$50	In Stock
100 mg	$65	In Stock
200 mg	$118	In Stock
500 mg	$222	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Product Introduction

Bioactivity

Description	Prochlorperazine Maleate (Capazine) is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS.
In vitro	Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy[2].
In vivo	Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole[1].
Cell Research	Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.(Only for Reference)
Alias	Prochlorperazin, Capazine, Prochlorperazine dimaleate salt, Stemetil, Compazine

Chemical Properties

Molecular Weight	606.09
Formula	C28H32ClN3O8S
Cas No.	84-02-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 2 mg/mL (3.3 mM)

DMSO: 45 mg/mL (74.25 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.6499 mL	8.2496 mL	16.4992 mL	82.4960 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.3300 mL	1.6499 mL	3.2998 mL	16.4992 mL
10 mM	0.1650 mL	0.8250 mL	1.6499 mL	8.2496 mL
20 mM	0.0825 mL	0.4125 mL	0.8250 mL	4.1248 mL
50 mM	0.0330 mL	0.1650 mL	0.3300 mL	1.6499 mL
100 mM	0.0165 mL	0.0825 mL	0.1650 mL	0.8250 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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