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Rilpivirine

🥰Excellent
Catalog No. T2330Cas No. 500287-72-9
Alias TMC278, R278474, DB08864

Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.

Rilpivirine

Rilpivirine

🥰Excellent
Purity: 98.83%
Catalog No. T2330Alias TMC278, R278474, DB08864Cas No. 500287-72-9
Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.
Pack SizePriceAvailabilityQuantity
2 mg$32In Stock
5 mg$50In Stock
10 mg$80In Stock
25 mg$148In Stock
50 mg$255In Stock
100 mg$378In Stock
500 mg$886In Stock
1 mL x 10 mM (in DMSO)$73In Stock
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Purity:98.83%
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Product Introduction

Bioactivity
Description
Rilpivirine (R278474) is a diarylpyrimidine derivative and reverse transcriptase inhibitor with antiviral activity against HIV-1 that is used in the treatment of HIV infections.
In vitro
Rilpivirine, dissolved in PEG 400 and administered via intravenous injection at dosages of 4 mg/kg in rats and 1.25 mg/kg in dogs, exhibits half-lives of 4.4 hours and 31 hours, respectively.
In vivo
Rilpivirine demonstrates antiviral activity against both wild-type and selective point single and double HIV-1 mutants, with an effective concentration (EC50) ranging from 0.1 to 2 nM.
AliasTMC278, R278474, DB08864
Chemical Properties
Molecular Weight366.42
FormulaC22H18N6
Cas No.500287-72-9
SmilesN(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2
Relative Density.1.27 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (150.1 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7291 mL13.6455 mL27.2911 mL136.4554 mL
5 mM0.5458 mL2.7291 mL5.4582 mL27.2911 mL
10 mM0.2729 mL1.3646 mL2.7291 mL13.6455 mL
20 mM0.1365 mL0.6823 mL1.3646 mL6.8228 mL
50 mM0.0546 mL0.2729 mL0.5458 mL2.7291 mL
100 mM0.0273 mL0.1365 mL0.2729 mL1.3646 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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