Shopping Cart
- Remove All
Your shopping cart is currently empty
Rilpivirine HCl
🥰Excellent
Catalog No. T2330LCas No. 700361-47-3
Alias TMC-278 hydrochloride, TMC278 hydrochloride, TMC 278. trade name Edurant, Rilpivirine hydrochloride, AQUIPTA
Rilpivirine HCl (Rilpivirine hydrochloride) is a selective and potent non-nucleoside reverse transcriptase inhibitor (NNRTI) with antiviral activity that inhibits the HIV virus and can be used in the study of HIV infections.
Rilpivirine HCl
🥰Excellent
Purity: 99.48%
Catalog No. T2330LAlias TMC-278 hydrochloride, TMC278 hydrochloride, TMC 278. trade name Edurant, Rilpivirine hydrochloride, AQUIPTACas No. 700361-47-3
Rilpivirine HCl (Rilpivirine hydrochloride) is a selective and potent non-nucleoside reverse transcriptase inhibitor (NNRTI) with antiviral activity that inhibits the HIV virus and can be used in the study of HIV infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $31 | In Stock | |
| 5 mg | $46 | In Stock | |
| 10 mg | $64 | In Stock | |
| 25 mg | $98 | In Stock | |
| 50 mg | $148 | In Stock | |
| 100 mg | $217 | In Stock | |
| 200 mg | $319 | In Stock | |
| 500 mg | $539 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Rilpivirine HCl"
Chloroquine phosphate
Cited
Chloroquine diphosphate, Chingamin phosphate, Aralen phosphate
T019450-63-5
Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
- $42
Size
QTY
CitedEdaravone
Cited
MCI-186
T040789-25-8
Edaravone (MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.
- $43
Size
QTY
CitedDexamethasone Cited
Prednisolone F, NSC 34521, MK 125, Hexadecadrol
T107650-02-2
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and IL receptor modulator with anti-inflammatory and immunosuppressive properties that induces autophagy and inhibits LPS-induced inflammatory responses in macrophages.
ADC CytotoxinAntibacterialAntibioticAutophagyComplement SystemGlucocorticoid ReceptorIL ReceptorMitophagySARS-CoV
- $29
Size
QTY
CitedSilymarin
Silybin B
T667065666-07-1
Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.
- $42
Size
QTY
EIDD-1931 Cited
Beta-d-N4-hydroxycytidine
T84983258-02-4
EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity that inhibits the replication of severe acute respiratory syndrome coronavirus [SARS-CoV] in Vero 76 cells, Middle East respiratory syndrome coronavirus [MERS-CoV] in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s = 0.1, 0.15, and 0.3 μM, respectively).
- $33
Size
QTY
CitedMolnupiravir
MK-4482, Lagevrio, EIDD-2801
T609512492423-29-5
Molnupiravir (EIDD-2801) is an isopropyl ester prodrug of the ribonucleoside analog EIDD-1931 with oral bioavailability. Molnupiravir can be used in the study of COVID-19, seasonal and pandemic influenza, and has broad-spectrum antiviral activity against multiple coronaviruses and influenza viruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV.
- $34
Size
QTY
Doxycycline Cited
Vibramycin, Doxytetracycline, Doxycyclinum, Doxiciclina
T1687564-25-0
Doxycycline (Doxiciclina) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline has antibacterial activity and antitumor activity.
- $45
Size
QTY
CitedAstragaloside IV Cited
AST-IV, AS-IV
T297384687-43-4
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
- $32
Size
QTY
CitedDoxycycline (hyclate) Cited
WC2031, Doxycycline hydrochloride hemiethanolate hemihydrate, Doxycycline hyclate
T1687L24390-14-5
Doxycycline hyclate (WC2031) belongs to the tetracycline class of antibiotics and is a broad-spectrum metalloproteinase (MMP) inhibitor with oral activity. Doxycycline hyclate has antibacterial activity and antitumor activity.
- $41
Size
QTY
CitedGlucosamine Cited
D-Glucosamine, Chitosamine
T04293416-24-8
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
- $50
Size
QTY
CitedHydroxychloroquine Cited
2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol
T9287118-42-3
Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it's also being studied as an experimental treatment for COVID-19.
- $30
Size
QTY
CitedRemdesivir Cited
GS-5734
T77661809249-37-3
Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viruses, and is potentially therapeutic against COVID-19.
- $122
Size
QTY
CitedSelect Batch
Purity:99.48%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rilpivirine HCl (Rilpivirine hydrochloride) is a selective and potent non-nucleoside reverse transcriptase inhibitor (NNRTI) with antiviral activity that inhibits the HIV virus and can be used in the study of HIV infections. |
| Targets&IC50 | HIV-1 (wild-type):EC50=0.4 nM |
| In vitro | Rilpivirine HCl showed significant activity against wild-type HIV-1 (EC50=0.4 nM) and activity ranged from EC50=0.1-2.0 nM against all single and double mutants tested. no indication of breakthrough of wild-type HIV-1 at 1 μM was observed with Rilpivirine HCl in 30-day experiments at concentrations ranging from 10 to 5000 nM. Rilpivirine HCl was able to inhibit 81% of clinical isolates (approximately 1,200 recombinant clinical isolates) with an EC50 of less than 1 nM and 94% of clinical isolates with an EC50 of less than 10 nM. [1] Rilpivirine HCl showed sub-nanomolar activity against HIV-1 Group M wild-type isolates with EC50s ranging from 0.07 to 1.01 nM. [2] |
| In vivo | Oral administration of Rilpivirine HCl in rats (10-160 mg/kg for 1 month) did not elicit significant abnormal responses, except for increased liver weight and species-specific thyroid hypertrophy observed at some of the higher doses. The elimination half-life of intravenously administered Rilpivirine HCl ranged from 4.4 hours in rats to 31 hours in dogs, with drug exposures (AUCinf) ranging from 3.1 μg-h/mL in rats (4 mg/kg), to 8.7 μg-h/mL in dogs (1.25 mg/kg), 1.4 μg-h/mL in monkeys (1.25 mg/kg), and 1.4 μg-h/mL in rabbits ( 1.25 mg/kg) and 44 μg-h/mL in rabbit (1.25 mg/kg). When administered orally, the half-life of Rilpivirine HCl was 2.8 hours in rats and 39 hours in dogs, with oral bioavailability of 32% and 31% in rats and dogs, respectively. [1] |
| Alias | TMC-278 hydrochloride, TMC278 hydrochloride, TMC 278. trade name Edurant, Rilpivirine hydrochloride, AQUIPTA |
| Molecular Weight | 402.88 |
| Formula | C22H19ClN6 |
| Cas No. | 700361-47-3 |
| Smiles | N(C1=C(C)C=C(/C=C/C#N)C=C1C)C2=NC(NC3=CC=C(C#N)C=C3)=NC=C2.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (248.21 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Rilpivirine HCl | purchase Rilpivirine HCl | Rilpivirine HCl cost | order Rilpivirine HCl | Rilpivirine HCl chemical structure | Rilpivirine HCl in vivo | Rilpivirine HCl in vitro | Rilpivirine HCl formula | Rilpivirine HCl molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.