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ROC-325

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Purity:99.26%

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COA HNMR HPLC

ROC-325

Catalog No. T16777Cas No. 1859141-26-6

ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity.

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Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$39	In Stock
5 mg	$58	In Stock
10 mg	$98	In Stock
25 mg	$198	In Stock
50 mg	$328	In Stock
100 mg	$473	In Stock
500 mg	Inquiry	In Stock

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Product Introduction

Bioactivity

Description	ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity.
In vitro	ROC-325 (5 μM) leads to the formation of LC3B punctae and a robust increase in LC3B levels in both A498 and 786-0 RCC cells. ROC-325 promotes a dose-dependent increase in LC3B expression in a manner that correlated with a corresponding increase in the levels of p62 and cathepsin D. ROC-325 inhibits cells growth with IC50 values of 4.9 μM, 11 μM, 4.6 μM, 5.4 μM, 7.4 μM, 11 μM, 8.2 μM, 5.8 μM, 5.0 μM, 11 μM, 8.4 μM and 6.0 μM for A498, A549, CFPAC-1, COLO-205, DLD-1, IGROV-1, MCF-7, MiaPaCa-2, NCI-H69, PC-3, RL and UACC-62 cells, respectively. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux[1].
In vivo	In mice bearing 786-0 RCC xenografts, ROC-325 (25, 40, and 50 mg/kg; oral) leads to significant, dose-dependent inhibition of disease progression and inhibits autophagy in vivo[1].

Chemical Properties

Molecular Weight	503.06
Formula	C28H27ClN4OS
Cas No.	1859141-26-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (59.64 mM)

H2O: 0.8 mg/mL (1.59 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.9878 mL	9.9392 mL	19.8783 mL	99.3917 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.3976 mL	1.9878 mL	3.9757 mL	19.8783 mL
10 mM	0.1988 mL	0.9939 mL	1.9878 mL	9.9392 mL
20 mM	0.0994 mL	0.4970 mL	0.9939 mL	4.9696 mL
50 mM	0.0398 mL	0.1988 mL	0.3976 mL	1.9878 mL
100 mM	0.0199 mL	0.0994 mL	0.1988 mL	0.9939 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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