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RS 67333 hydrochloride

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Purity:98.78%

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COA HNMR LCMS

RS 67333 hydrochloride

Catalog No. T23265Cas No. 168986-60-5

RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer's disease research.

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Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$73	In Stock
25 mg	$172	In Stock
50 mg	$271	In Stock
100 mg	$397	In Stock
1 mL x 10 mM (in DMSO)	$47	In Stock

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Product Introduction

Bioactivity

Description	RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer's disease research.
In vitro	RS 67333 hydrochloride exhibits affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT [1].
Alias	RS 67333 (hydrochloride), RS 67333 HCl

Chemical Properties

Molecular Weight	389.36
Formula	C19H30Cl2N2O2
Cas No.	168986-60-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 9mg/ml (23.1mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0514 mL	0.2568 mL	0.5137 mL	2.5683 mL
100 mM	0.0257 mL	0.1284 mL	0.2568 mL	1.2842 mL

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