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S 3304

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Purity:96.78%

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COA LCMS HNMR HPLC

S 3304

Catalog No. T16966Cas No. 203640-27-1

S 3304 is a novel matrix metalloproteinases inhibitor which is specific for MMP-2 and MMP-9.

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Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$272	In Stock
10 mg	$455	In Stock
25 mg	$753	In Stock
50 mg	$1,060	In Stock
100 mg	$1,430	In Stock
500 mg	$2,860	In Stock
1 mL x 10 mM (in DMSO)	$277	In Stock

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Product Introduction

Bioactivity

Description	S 3304 is a novel matrix metalloproteinases inhibitor which is specific for MMP-2 and MMP-9.
In vitro	S 3304 is a novel D-tryptophan derivative and a potent, noncytotoxic Matrix metalloproteinases inhibitor. S 3304 most effectively inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors [1].
In vivo	S 3304 (p.o., the dose range of 20 to 200 mg/kg) treatment, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 cause effective inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen [1].

Chemical Properties

Molecular Weight	464.56
Formula	C24H20N2O4S2
Cas No.	203640-27-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.3 mg/mL (179.31 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1526 mL	10.7629 mL	21.5257 mL	107.6287 mL
5 mM	0.4305 mL	2.1526 mL	4.3051 mL	21.5257 mL
10 mM	0.2153 mL	1.0763 mL	2.1526 mL	10.7629 mL
20 mM	0.1076 mL	0.5381 mL	1.0763 mL	5.3814 mL
50 mM	0.0431 mL	0.2153 mL	0.4305 mL	2.1526 mL
100 mM	0.0215 mL	0.1076 mL	0.2153 mL	1.0763 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc