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SB-334867 free base
🥰Excellent
Catalog No. T6140Cas No. 792173-99-0
Alias SB334867A free base, SB-334867, SB334867, SB 334867
SB-334867 free base (SB334867A free base) is a selective antagonist of the orexin-1 (OX1) receptor.
SB-334867 free base
🥰Excellent
Purity: 100%
Catalog No. T6140Alias SB334867A free base, SB-334867, SB334867, SB 334867Cas No. 792173-99-0
SB-334867 free base (SB334867A free base) is a selective antagonist of the orexin-1 (OX1) receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $64 | In Stock | |
| 10 mg | $100 | In Stock | |
| 25 mg | $163 | In Stock | |
| 50 mg | $238 | In Stock | |
| 100 mg | $355 | In Stock | |
| 200 mg | $528 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $71 | In Stock |
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YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), with EC50 values of 0.028 μM for OX2R and 2.75 μM for OX1R. Additionally, YNT-185 effectively alleviates symptoms of narcolepsy-cataplexy in mouse models.
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | SB-334867 free base (SB334867A free base) is a selective antagonist of the orexin-1 (OX1) receptor. |
| Targets&IC50 | OXB:100 nM, OXA:10 nM |
| In vitro | In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response. [1] |
| In vivo | In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. [2] SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. [3] SB-334867 also inhibits the development of morphine analgesic tolerance in rats. [4] |
| Alias | SB334867A free base, SB-334867, SB334867, SB 334867 |
| Molecular Weight | 319.32 |
| Formula | C17H13N5O2 |
| Cas No. | 792173-99-0 |
| Smiles | N(C(NC=1C=C2C(=CC1)N=C(C)O2)=O)C=3C4=C(N=CC3)C=CC=N4 |
| Relative Density. | 1.472 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 3.2 mg/mL (10 mM)), Heating is recommended. DMSO: 31.9 mg/mL (100 mM), Heating is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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