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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $32 | In Stock | |
2 mg | $45 | In Stock | |
5 mg | $68 | In Stock | |
10 mg | $105 | In Stock | |
25 mg | $221 | In Stock | |
50 mg | $387 | In Stock | |
100 mg | $576 | In Stock | |
1 mL x 10 mM (in DMSO) | $68 | In Stock |
Description | SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist. |
In vitro | In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response. [1] |
In vivo | In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. [2] SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. [3] SB-334867 also inhibits the development of morphine analgesic tolerance in rats. [4] |
Alias | SB334867A free base, SB-334867, SB 334867, SB334867 |
Molecular Weight | 319.32 |
Formula | C17H13N5O2 |
Cas No. | 792173-99-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 3.2 mg/mL (10 mM)) DMSO: 31.9 mg/mL (100 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
DMSO
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