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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $148 | In Stock | |
5 mg | $336 | In Stock | |
10 mg | $497 | In Stock | |
25 mg | $793 | In Stock | |
50 mg | $1,130 | In Stock | |
100 mg | $1,520 | In Stock | |
1 mL x 10 mM (in DMSO) | $417 | In Stock |
Description | Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect . |
In vivo | Sivopixant (S-600918) was identified as a clinical candidate with potent and selective antagonistic activity (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM) and a strong analgesic effect in the rat partial sciatic nerve ligation model (Seltzer model) of allodynia (ED50, 0.4 mg/kg). |
Alias | S-600918, Sivopixant |
Molecular Weight | 507.93 |
Formula | C25H22ClN5O5 |
Cas No. | 2414285-40-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (108.28 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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