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Sonlicromanol hydrochloride

TargetMol
Catalog No. T38013Cas No. 2162149-24-6
Alias KH 176 hydrochloride

Sonlicromanol hydrochloride (KH176 hydrochloride) is a ROS-redox modulator that crosses the blood-brain barrier, has potential anticancer activity, improves m.3243A>G heterogeneity in iPSC-derived neurons associated with It has potential anticancer activity, ameliorates neuronal network dysfunction and transcriptomic changes associated with m.3243A>G heterogeneity in iPSC-derived neurons, and can be used for the treatment of mitochondrial diseases.

Sonlicromanol hydrochloride

Sonlicromanol hydrochloride

TargetMol
Purity: 99.53%
Catalog No. T38013Alias KH 176 hydrochlorideCas No. 2162149-24-6
Sonlicromanol hydrochloride (KH176 hydrochloride) is a ROS-redox modulator that crosses the blood-brain barrier, has potential anticancer activity, improves m.3243A>G heterogeneity in iPSC-derived neurons associated with It has potential anticancer activity, ameliorates neuronal network dysfunction and transcriptomic changes associated with m.3243A>G heterogeneity in iPSC-derived neurons, and can be used for the treatment of mitochondrial diseases.
Pack SizePriceAvailabilityQuantity
1 mg$158In Stock
5 mg$396In Stock
10 mg$662In Stock
25 mg$1,360In Stock
50 mg$1,980In Stock
100 mg$2,500In Stock
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Purity:99.53%
ee:100%
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Product Introduction

Bioactivity
Description
Sonlicromanol hydrochloride (KH176 hydrochloride) is a ROS-redox modulator that crosses the blood-brain barrier, has potential anticancer activity, improves m.3243A>G heterogeneity in iPSC-derived neurons associated with It has potential anticancer activity, ameliorates neuronal network dysfunction and transcriptomic changes associated with m.3243A>G heterogeneity in iPSC-derived neurons, and can be used for the treatment of mitochondrial diseases.
In vivo
In Ndufs4−/− mice (Leigh Disease model), Sonlicromanol hydrochloride (10 mg/kg; intraperitoneal injection, once daily) significantly improved rotarod and gait performance, reduced degeneration of retinal ganglion cells. Additionally, it resulted in significantly higher FA values in the external capsule and showed a similar trend in the cerebral peduncle[1].
AliasKH 176 hydrochloride
Chemical Properties
Molecular Weight368.9
FormulaC19H29ClN2O3
Cas No.2162149-24-6
Storage & Solubility Information
Storagestore under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 150 mg/mL (406.61 mM), Sonification is recommended.
H2O: 80 mg/mL (216.86 mM.)
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.7108 mL13.5538 mL27.1076 mL135.5381 mL
5 mM0.5422 mL2.7108 mL5.4215 mL27.1076 mL
10 mM0.2711 mL1.3554 mL2.7108 mL13.5538 mL
20 mM0.1355 mL0.6777 mL1.3554 mL6.7769 mL
50 mM0.0542 mL0.2711 mL0.5422 mL2.7108 mL
100 mM0.0271 mL0.1355 mL0.2711 mL1.3554 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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