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Sonlicromanol hydrochloride (KH176 hydrochloride) is a ROS-redox modulator that crosses the blood-brain barrier, has potential anticancer activity, improves m.3243A>G heterogeneity in iPSC-derived neurons associated with It has potential anticancer activity, ameliorates neuronal network dysfunction and transcriptomic changes associated with m.3243A>G heterogeneity in iPSC-derived neurons, and can be used for the treatment of mitochondrial diseases.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $158 | In Stock | |
5 mg | $396 | In Stock | |
10 mg | $662 | In Stock | |
25 mg | $1,360 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,500 | In Stock |
Description | Sonlicromanol hydrochloride (KH176 hydrochloride) is a ROS-redox modulator that crosses the blood-brain barrier, has potential anticancer activity, improves m.3243A>G heterogeneity in iPSC-derived neurons associated with It has potential anticancer activity, ameliorates neuronal network dysfunction and transcriptomic changes associated with m.3243A>G heterogeneity in iPSC-derived neurons, and can be used for the treatment of mitochondrial diseases. |
In vivo | In Ndufs4−/− mice (Leigh Disease model), Sonlicromanol hydrochloride (10 mg/kg; intraperitoneal injection, once daily) significantly improved rotarod and gait performance, reduced degeneration of retinal ganglion cells. Additionally, it resulted in significantly higher FA values in the external capsule and showed a similar trend in the cerebral peduncle[1]. |
Alias | KH 176 hydrochloride |
Molecular Weight | 368.9 |
Formula | C19H29ClN2O3 |
Cas No. | 2162149-24-6 |
Storage | store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 150 mg/mL (406.61 mM), Sonification is recommended. H2O: 80 mg/mL (216.86 mM.) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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