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UC-514321

UC-514321
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Purity:97%
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UC-514321

Catalog No. T13950Cas No. 299420-83-0
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
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Pack SizePriceAvailabilityQuantity
1 mg$85In Stock
5 mg$198In Stock
10 mg$376In Stock
25 mg$637In Stock
50 mg$888In Stock
100 mg$1,230In Stock
1 mL x 10 mM (in DMSO)$229In Stock
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Product Introduction

Bioactivity
Description
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
In vitro
UC-514321 (0-500 nM, 48 h) inhibits AML cells viability TET1-signaling dependently.UC-514321 increases apoptosis in AML cells not in normal HSPCs.
In vivo
In AML mice models, UC-514321 (2.5 mg/kg, i.p., once per day, for 10 days) exhibits more potent anti-tumor activity than NSC370284.
Chemical Properties
Molecular Weight441.56
FormulaC26H35NO5
Cas No.299420-83-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 25 mg/mL (55.62 mM), Sonication is recommended.
H2O: 50 mg/mL (113.23 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.2647 mL11.3235 mL22.6470 mL113.2349 mL
5 mM0.4529 mL2.2647 mL4.5294 mL22.6470 mL
10 mM0.2265 mL1.1323 mL2.2647 mL11.3235 mL
20 mM0.1132 mL0.5662 mL1.1323 mL5.6617 mL
50 mM0.0453 mL0.2265 mL0.4529 mL2.2647 mL
H2O
1mg5mg10mg50mg
100 mM0.0226 mL0.1132 mL0.2265 mL1.1323 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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