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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $2,230 | In Stock |
Description | ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 μM against A549 cells.ULK1-IN-2 can be used for the study of non-small-cell lung cancer. |
In vitro | ULK1-IN-2 (compound 3s) (10 μM; 24 h) exhibits potent anti-proliferative activity against A549, U937, HL60, MDA-MB-468, and MCF-7 cells. In A549 cells, ULK1-IN-2 inhibits autophagy by targeting ULK1 and induces apoptosis via mitochondrial pathways in a dose-dependent manner. It also reduces ULK1 and p-ULK1ser317 expression in a concentration-dependent manner, significantly decreasing Bcl-2 expression while increasing Bax and active Caspase-3 expression.[1] |
Molecular Weight | 495.26 |
Formula | C19H16BrFN4O6 |
Cas No. | 2497409-01-3 |
Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (90.86 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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