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ZT-12-037-01
Catalog No. T5597Cas No. 2328073-61-4
Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
ZT-12-037-01
Catalog No. T5597Cas No. 2328073-61-4
Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $68 | In Stock | |
| 10 mg | $117 | In Stock | |
| 25 mg | $236 | In Stock | |
| 50 mg | $396 | In Stock | |
| 100 mg | $619 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock |
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Purity:99.56%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively). |
| Targets&IC50 | STK19 (WT):23.96 nM , STK19 (D89N):27.94 nM |
| In vitro | ZT-12-037-01 significantly inhibits mutant NRAS-STK19-driven melanocyte colony formation and proliferation. |
| In vivo | ZT-12-037-01 as a specific STK19-targeted inhibitor and it effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vivo. |
| Animal Research | ZT-12-037-01 (injection subcutaneously; 25-50 mg/kg; once daily; 21 days) inhibits growth of SK-MEL-2 xenograft melanoma and the sections of tumors indicates induction of apoptosis by increasing cleaved caspase-3. |
| Molecular Weight | 385.5 |
| Formula | C21H31N5O2 |
| Cas No. | 2328073-61-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 41 mg/mL (106.36 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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