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(S)-10-Hydroxycamptothecin

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Purity:99.48%

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COA HNMR HPLC

(S)-10-Hydroxycamptothecin

Catalog No. T2764Cas No. 19685-09-7

(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.

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Pack Size	Price	Availability
25 mg	$44	In Stock
50 mg	$60	In Stock
100 mg	$84	In Stock
500 mg	$196	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock

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Product Introduction

Bioactivity

Description	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
In vitro	In the CAM model, 10-Hydroxycamptothecin (25 nM) inhibits angiogenesis in a concentration-dependent manner. In mice carrying Colo 205 xenografts, oral administration of 10-Hydroxycamptothecin (2.5-7.5 mg/kg) every two days significantly suppresses tumor cell growth.
In vivo	(S)-10-Hydroxycamptothecin inhibits cell growth in BT-20 cells (IC50=34.3 nM) and MDA-231 cells (IC50=7.27 nM), demonstrating its efficacy. It also induces the formation of cleavable complexes mediated by human topoisomerase I in pBR322 plasmid DNA (EC50=0.35 μM). Additionally, in human microvascular endothelial cells (HMEC), (S)-10-Hydroxycamptothecin dose-dependently inhibits cell growth (IC50=0.31 μM), significantly hampers HMEC migration (IC50=0.63 μM), and impedes angiogenesis (IC50=0.96 μM).
Cell Research	Cells are exposed to various concentrations of 10-Hydroxycamptothecin for 72 hours. Cell growth is monitored by the standard MTT assay.(Only for Reference)
Alias	10-Hydroxycamptothecin, 10-HCPT

Chemical Properties

Molecular Weight	364.35
Formula	C20H16N2O5
Cas No.	19685-09-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (54.89 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0274 mL	0.1372 mL	0.2745 mL	1.3723 mL

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In Vivo Formulation Calculator (Clear solution)

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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