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9-ING-41

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Purity:99.25%

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COA HNMR HPLC

9-ING-41

Catalog No. T14066Cas No. 1034895-42-5

9-ING-41 is a glycogen synthase kinase-3 inhibitor.

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Pack Size	Price	Availability
1 mg	$45	In Stock
2 mg	$64	In Stock
5 mg	$101	In Stock
10 mg	$166	In Stock
25 mg	$343	In Stock
50 mg	$497	In Stock
100 mg	$742	In Stock
1 mL x 10 mM (in DMSO)	$118	In Stock

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Product Introduction

Bioactivity

Description	9-ING-41 is a glycogen synthase kinase-3 inhibitor.
In vitro	9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis[2]. 9-ING-41 (1, 2 μM; 24 hours) is a potent cell cycle-blocking agent for lymphoma cells[2]. 9-ING-41 (0.1-1 μM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker[1]. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM[2].
In vivo	In a mouse model of MCL, 9-ING-41 (40 mg/kg/every other day; for 17 days) has single-agent antitumor activity [2].

Chemical Properties

Molecular Weight	404.35
Formula	C22H13FN2O5
Cas No.	1034895-42-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 97 mg/mL (239.89 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4731 mL	12.3655 mL	24.7310 mL	123.6552 mL
5 mM	0.4946 mL	2.4731 mL	4.9462 mL	24.7310 mL
10 mM	0.2473 mL	1.2366 mL	2.4731 mL	12.3655 mL
20 mM	0.1237 mL	0.6183 mL	1.2366 mL	6.1828 mL
50 mM	0.0495 mL	0.2473 mL	0.4946 mL	2.4731 mL
100 mM	0.0247 mL	0.1237 mL	0.2473 mL	1.2366 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc