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A-3 hydrochloride

Catalog No. T14069 CAS 78957-85-4

Synonyms: Calmodulin-dependent kinases, CaMK, inhibit, Casein Kinase, PKC, inhibitor, PKA, A 3 hydrochloride, cAMP, calmodulin, kinase, A-3, MLC-kinase, Calmodulin-dependent protein kinases, Protein kinase C, Protein kinase A, A 3, casein, A3 hydrochloride

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM).

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A-3 hydrochloride, CAS 78957-85-4

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Purity: 98%

Biological Description

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Description	A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1]. A-3 hydrochloride against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM).
Targets&IC50	PKC:47 μM （ki）, PKA:4.3 μM （ki）, CK2:5.1 μM （ki）, CK1:80 μM （ki）
In vitro	A-3 hydrochloride inhibits MLC-kinase competitively with respect to ATP and that the Ki value is 7.4 μM, and it is also a competitive inhibitor of cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II, with respect to ATP, exhibits Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively[1].

Synonyms	Calmodulin-dependent kinases, CaMK, inhibit, Casein Kinase, PKC, inhibitor, PKA, A 3 hydrochloride, cAMP, calmodulin, kinase, A-3, MLC-kinase, Calmodulin-dependent protein kinases, Protein kinase C, Protein kinase A, A 3, casein, A3 hydrochloride
Molecular Weight	321.22
Formula	C12H14Cl2N2O2S
CAS No.	78957-85-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (389.14 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Inagaki M, et al. Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol. 1986 Jun;29(6):577-81.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library GPCR Compound Library Inhibitor Library Wnt/Hedgehog/Notch Compound Library Anti-Metabolism Disease Compound Library Kinase Inhibitor Library Stem Cell Differentiation Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compound Library Tyrosine Kinase Inhibitor Library

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