Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 213.00 | |
10 mg | In stock | $ 343.00 | |
25 mg | In stock | $ 583.00 | |
50 mg | In stock | $ 835.00 | |
100 mg | In stock | $ 1,150.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec |
Targets&IC50 | CDK5-p35:40 nM, CDK2-CyclinA:15 nMCD, K2/Cyc E:200 nM, CDK1-CyclinB:35 nM |
In vitro | Alsterpaullone inhibited HeLa cells in a time-dependent (0-72 h) and dose-dependent (0-30 μ M) manner.?In the presence of alsterpaullone, HeLa cells were arrested in G2/M prior to undergoing apoptosis via a mechanism that is involved in the regulation of various antiapoptotic genes, DNA-repair, transcription, and cell cycle progression.?Compared to controls, alsterpaullone effectively prevented HeLa cells from entering S-phase.?These potential therapeutic efficacies could be correlated with the activation of caspase-3[1]. |
Molecular Weight | 293.28 |
Formula | C16H11N3O3 |
CAS No. | 237430-03-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (40.92 mM)
You can also refer to dose conversion for different animals. More
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ALSTERPAULLONE 237430-03-4 Apoptosis Cell Cycle/Checkpoint PI3K/Akt/mTOR signaling Stem Cells GSK-3 CDK CDK5 p35 NSC-705701 9-Nitropaullone NSC705701 Glycogen synthase kinase-3 cyclin E Glycogen synthase kinase 3 Cyclin dependent kinase inhibit NSC 705701 antitumor CDK2 cyclin A cyclin B Inhibitor CDK1 neurodegenerative inhibitor