Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 43.00 | |
25 mg | In stock | $ 81.00 | |
50 mg | In stock | $ 147.00 | |
100 mg | In stock | $ 218.00 | |
200 mg | In stock | $ 323.00 | |
500 mg | In stock | $ 543.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols. |
Targets&IC50 | human cytochromebc1:460 nM (IC50), P. falciparumcytochromebc1:2.0 nM (IC50) |
In vitro | Atovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity.[1] Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. [2] |
In vivo | Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. [3] |
Synonyms | Atavaquone |
Molecular Weight | 366.84 |
Formula | C22H19ClO3 |
CAS No. | 95233-18-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.3 mg/mL (20 mM)
You can also refer to dose conversion for different animals. More
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Atovaquone 95233-18-4 Metabolism Microbiology/Virology Others P450 Dehydrogenase Antibiotic Parasite CYPs Plasmodium malaria Cytochrome P450 Inhibitor Atavaquone neumocystis toxoplasmosis pneumonia inhibit babesia inhibitor