Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-202 (PD1-PDL1 inhibitor 2) is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 57.00 | |
5 mg | In stock | $ 102.00 | |
10 mg | In stock | $ 163.00 | |
25 mg | In stock | $ 323.00 | |
50 mg | In stock | $ 577.00 | |
100 mg | In stock | $ 634.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 108.00 |
Description | BMS-202 (PD1-PDL1 inhibitor 2) is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction. |
Targets&IC50 | PD-1/PD-L1:0.018 μM |
In vitro | BMS-202 inhibits PD-1/PD-Ll interaction, and may augment therapeutic immune response to a number of histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems[1]. |
Kinase Assay | All binding studies are performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (with v) bovine serum albumin and 0.05% (v/v) Tween-20. For the PD-l-Ig/PD-Ll-His binding assay, inhibitors are pre-incubated with PD-Ll-His (10 nM final) for 15 m in 4 μL of assay buffer, followed by addition of PD-l-Ig (20 nM final) in 1 μL of assay buffer and further incubation for 15 m. PD-L1 from either human, cyno, or mouse are used. HTRF detection is achieved using europium crypate-labeled anti- Ig (1 nM final) and allophycocyanin (APC) labeled anti-His (20 nM final). Antibodies are diluted in HTRF detection buffer and 5 μL is dispensed on top of binding reaction. The reaction mixture is allowed to equilibrate for 30 minutes and signal (665 nm/620 nm ratio) is obtained using an En Vision fluorometer. Additional binding assays are established between PD-1-Ig/PD-L2-His (20, 5 nM, respectively), CD80-His/PD-Ll-Ig (100, 10 nM, respectively) and CD80-His/CTLA4-Ig (10, 5 nM, respectively). |
Synonyms | PD1-PDL1 inhibitor 2, PD-1/PD-L1 inhibitor 2 |
Molecular Weight | 419.52 |
Formula | C25H29N3O3 |
CAS No. | 1675203-84-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 76 mg/mL(181.2 mM)
Ethanol: 83 mg/mL (197.85 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BMS-202 1675203-84-5 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 BMS202 antitumor PD1-PDL1 inhibitor 2 PD-1/PD-L1 inhibitor 2 dimeric anti-proliferation BMS 202 nonpeptidic immune-response Thermal stabilization Inhibitor inhibit hydrophobic inhibitor