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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $42 | In Stock | |
2 mg | $58 | In Stock | |
5 mg | $98 | In Stock | |
10 mg | $153 | In Stock | |
25 mg | $245 | In Stock | |
50 mg | $368 | In Stock | |
100 mg | $547 | In Stock | |
500 mg | $1,190 | In Stock | |
1 mL x 5 mM (in DMSO) | $98 | In Stock |
Description | Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
In vivo | To evaluate the efficacy of NVS-SM1, we used the SMNΔ7 mouse model, which displays a severe phenotype. In the specific colony used for this study, death typically occurs before postnatal day 15. We were pleased to observe that, in addition to a dose-dependent elevation of SMN protein in the brain, oral administration of NVS-SM1 improved body weight and extended lifespan, with 50% of the animals in the 1 mg per kg body weight group and 62% of animals in the 3 mg per kg body weight group showing increased survival. |
Alias | LMI 070, NVS-SM1 |
Molecular Weight | 393.48 |
Formula | C22H27N5O2 |
Cas No. | 1562338-42-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
Solubility Information | DMSO: 3.8 mg/mL (9.6 mM), Sonication and heating are recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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