Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
2 mg | In stock | $ 44.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 192.00 | |
50 mg | In stock | $ 289.00 | |
100 mg | In stock | $ 455.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 125.00 |
Description | CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network. |
In vitro | CPTH2 decreases cell viability, adhesion, and invasiveness in ccRCC cell line 786-O. It shows preferential inhibition for KAT3B-p300 with hypoacetilating effects on histone H3 at specific H3-K18. Immunohistochemical analysis of 70 ccRCC tumor tissues compared with peritumoral normal epithelium showed a statistical significant reduction of p300/H3AcK18 paralleled by an increase of H3AcK14 in G1 grade and an opposed trend during tumor progression to worst grades[1]. |
Molecular Weight | 291.8 |
Formula | C14H14ClN3S |
CAS No. | 357649-93-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (34.27 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CPTH2 357649-93-5 Apoptosis Chromatin/Epigenetic Histone Acetyltransferase histone Inhibitor acetyltransferase ccRCC HAT CPTH 2 Gcn5p CPTH-2 KAT3B carcinoma HATs inhibit inhibitor