kat3b

Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b negatively regulates p85 in an independent proteolytic manner, and participates in the recruitment of p85 to CD28 and T cell antigen receptor ζ through its E3 ubiquitin ligase activity. Inhibition of PI3K inhibits the enhancement of Cblb-/ -T cell activation.

Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including diabetes, cardiovascular disease, bloo

sodium 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate is an organosulfur compound. It has been used as a model compound to study the effects of sulfur-containing compounds on enzymatic activities and metabolic pathways. It has also been used to study the effects of sulfur-containing compounds on the regulation of bacterial growth and gene expression.

b-Casomorphin (1-3) Acetate is a tri-peptide with an opioid effect.

3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.

Tenacigenin B, a component of the plant Poria cocos, is identified as 3-O-β-Allopyranosyl-(1→4).

4,5-Dihydroxy-2-((5-methyl-3,8-dimethylene-2-oxododecahydroazuleno[6,5-b]furan-5-yl)oxy)tetrahydro-2H-pyran-3-yl acetate is an α-arabinopyranosides analogue isolated from the aboveground parts of barley [1].

3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings.

Quercetin-3-O-β-D-galactopyranosyl-(1→6)-β-D-glucopyranoside (compound 1), a flavonoid glycoside, is extractable from M. delavayi leaves [1].

25-O-Acetyl-7,8-didehydro-cimigenol-3-O-β-D-xylopyranoside is a cycloartane triterpenoid isolated from Cimicifuga acerina [1].

5-Acetyl-3-chloro-10,11-dihydro-5H-dibenz[b,f]azepine is a useful organic compound for research related to life sciences. The catalog number is T67591 and the CAS number is 25961-11-9.

DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram-positive strains [1].

Nucleoside Derivatives - 8-Aza-7-deaza purine nucleosides, Halo-nucleosides

Quercetin 3-O-(6-O-malonyl)-b-D-glucoside is a useful organic compound for research related to life sciences. The catalog number is T123838 and the CAS number is 96862-01-0.

Nucleoside Derivatives - 7-Deaza-8-aza purine nucleosides; Halo-nucleosides; 6-Modified purine nucleosides

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66536 and the CAS number is 256376-65-5.

3-Epimeliasenin B is a natural product for research related to life sciences. The catalog number is TN5953 and the CAS number is 1222475-77-5.

1-b-D-(3-Methoxy naphthalen-2-yl)-2’-deoxyriboside; 1,4-Anhydro-2-deoxy-1-C-(3-methoxy)-naphthalenyl)-D-erythro-pentitol is a useful organic compound for research related to life sciences. The catalog number is TNU1641 and the CAS number is 1117893-19-2.

(S)-2-Amino-3-(benzo[b]thiophen-3-yl)propanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66164 and the CAS number is 72120-71-9.

Nucleoside Derivatives –Fluoro-modified nucleosides, 6-Modified purine nucleosides, 3’-Modified nucleosides

hMAO-B-IN-3 (Compound 15) is a potent hMAO-B inhibitor (IC 50 = 47.4 nM) with favourable drug-like properties and a broad safety window. Therefore, hMAO-B-IN-3 is a suitable candidate for lead optimization and multitarget-directed ligands development [1].

3-epi-Isocucurbitacin B is a natural product for research related to life sciences. The catalog number is TN5972 and the CAS number is 89647-62-1.

Factor B-IN-3 is a potent inhibitor of complement factor B. Factor B-IN-3 can be used to study inflammatory and immune-related diseases.

4-Amino-6-bromo-5-cyano-1-(3-deoxy-3-fluoro-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1039.

Nucleoside Derivatives - Amino-nucleosides, Xylo-nucleosides, 2’,3’-Didexoy nucleosides, 3’-Modified nucleosides

AChE/BChE/MAO-B-IN-3, an indan-1-one derivative, serves as a potent inhibitor of human monoamine oxidase B (MAO-B) with an IC50 of 0.0359 μM, demonstrating significant inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 0.0473 μM and 0.0782 μM, respectively. Exhibiting notable antioxidant activity, AChE/BChE/MAO-B-IN-3 holds considerable promise for Alzheimer's disease (AD) research.

(2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one is a useful organic compound for research related to life sciences. The catalog number is T65968 and the CAS number is 42399-49-5.

Benzo[b]thiophene-3-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66350 and the CAS number is 24434-84-2.

3'-b-Amino-2',3'-dideoxy-5'-O-methoxytrityl-5-methyluridine is a Nucleoside Derivative - Amino-nucleoside, Xylo-nucleoside, 2',3'-Didexoy nucleoside, 3'-Modified nucleoside; Protected nucleoside with NH2/OH group.

3-Hexen-1-ol O-b-D-glucopyranoside is a useful organic compound for research related to life sciences. The catalog number is T123861 and the CAS number is 95632-87-4.

Methyl 8-hydroxy-3-(2-methoxy-2-oxoethyl)-6-methyl-9-oxo-9H-furo[3,4-b]chromene-1-carboxylate is a natural product for research related to life sciences. The catalog number is TN4537 and the CAS number is 96287-41-1.

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine 3'-CE phosphoramidite is a Nucleoside Phosphoramidite.

Kaempferol 3-b-laminaribioside is a useful organic compound for research related to life sciences. The catalog number is T124263 and the CAS number is 75836-21-4.

Nucleosides and Reagents - Fluoro-modified nucleoside; pyridine nucleoside

Nucleoside; Used for nucleoside and nucleic acid modification

AChE/MAO-B-IN-3 is a dual inhibitor targeting both acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), exhibiting inhibitory concentrations (IC50s) of 0.0257 μM and 0.0456 μM against human AChE and MAO-B, respectively. This compound holds potential for Alzheimer’s disease research.

3'-b-Amino-2',3'-dideoxy-5'-O-methoxy trityluridine is a Nucleoside Derivative - Amino-nucleoside, Xylo-nucleoside, 2',3'-Didexoy nucleoside, 3'-Modified nucleoside; Protected nucleoside with NH2/OH group.

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67294 and the CAS number is 6052-68-2.

2',3',5'-Tri-O-benzoyl-2'-b-C-methyl-6-azauridine is a Nucleoside Derivative - 6-Aza-uridine; 2'-Modified nucleoside.

3-O-[b-D-Apiofuranosyl-(1-2)-[b-D-glucopyranosyl-( is a useful organic compound for research related to life sciences and the catalog number is T131100.

Nucleoside Derivatives - 7-Deaza-purine nucleosides; 3’-Modified nucleosides; Fluoro-modified nucleosides

MAO-B-IN-3 is a reversible, selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and demonstrates affinity for the 5-HT6 receptor with a Ki of 696 nM, making it suitable for Alzheimer's disease research [1].

Nucleoside Derivatives - 5-Modified pyrimidine nucleoside; 2’-Modified nucleoside; Protected nucleosides with NH2/OH open

6-Amino-3-(furan-2-yl)-4-methoxy-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 8-Aza-7-deaza-purine nucleoside; 6-Modified purine nucleoside.

4-Amino-6-bromo-5-cyano-1-(3-deoxy-3-fluoro-2-O-acetyl-5-(O-p-toluoyl)-b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine is a useful organic compound for research related to life sciences and the catalog number is TNU1038.

(S)-9-((tert-Butyldimethylsilyl)oxy)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione is a useful organic compound for research related to life sciences and the catalog number is T64821.

6-Amino-3-ethynyl-4-methoxy-1-(b-D-ribofuranosyl)-1H- pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 8-Aza-7-deaza-purine nucleoside; 6-Modified purine nucleoside.

Nucleoside Derivatives - 7-Deazapurine nucleosides; Halo-nucleosides; Scaffolds and Templates

(S)-tert-Butyl 2-(3-amino-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetate is a useful organic compound for research related to life sciences. The catalog number is T65674 and the CAS number is 109010-60-8.

6-Amino-3-iodo-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one is a useful organic compound for research related to life sciences and the catalog number is TNU0282.