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Clofarabine

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Purity:100%

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COA LCMS HNMR

Clofarabine

Catalog No. T0297Cas No. 123318-82-1

Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.

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Pack Size	Price	Availability
5 mg	$36	In Stock
10 mg	$54	In Stock
25 mg	$87	In Stock
50 mg	$135	In Stock
100 mg	$175	In Stock
200 mg	$227	In Stock
500 mg	$379	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
In vitro	In athymic nude mice or severe combined immunodeficient (SCID) mice, Clofarabine demonstrates inhibitory effects on various subcutaneously transplanted human tumor xenografts.
In vivo	In lymphocytes from chronic lymphocytic leukemia, 10 μM Clofarabine inhibits the repair induced by 4-hydroperoxycyclophosphamide with a peak inhibition at an intracellular concentration of 5 μM. Across a range of leukemia and solid tumor cell lines, Clofarabine demonstrates potent growth inhibition and cytotoxicity (IC50= 0.028–0.29 μM).
Alias	Clofarex, Evoltra, Clolar

Chemical Properties

Molecular Weight	303.68
Formula	C10H11ClFN5O3
Cas No.	123318-82-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (131.72 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2929 mL	16.4647 mL	32.9294 mL	164.6470 mL
5 mM	0.6586 mL	3.2929 mL	6.5859 mL	32.9294 mL
10 mM	0.3293 mL	1.6465 mL	3.2929 mL	16.4647 mL
20 mM	0.1646 mL	0.8232 mL	1.6465 mL	8.2323 mL
50 mM	0.0659 mL	0.3293 mL	0.6586 mL	3.2929 mL
100 mM	0.0329 mL	0.1646 mL	0.3293 mL	1.6465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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