clofarabine

Clofarabine (Clofarex)m, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.

2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis. The anticancer mechanism of 2'-Deoxy-2'-fluoro-beta-D-arabinoguanosine is dependent on the inhibition of DNA synthesis.

1-(β-D-Xylofuranosyl)-N6-Isopentenyladenine is an adenosine analog that primarily functions as a smooth muscle vasodilator and has been shown to inhibit cancer progression. Notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

3’-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine is an adenosine analog. Adenosine analogs primarily act as smooth muscle vasodilators and have also demonstrated inhibition of cancer progression. Notable related compounds include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog, primarily acting as a smooth muscle vasodilator and inhibiting cancer progression. Popular products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

1-(β-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine is an adenosine analog that predominantly functions as a smooth muscle vasodilator and has been shown to inhibit cancer progression. Its notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

2-Diethoxymethyl adenosine is an adenosine analog primarily acting as a smooth muscle vasodilator and inhibiting cancer progression. Notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine is an adenosine analog that primarily functions as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. Its notable derivatives include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

2'-O-Methyladenosine 5'-monophosphate triethyl ammonium is an adenosine analog that primarily functions as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. Its notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

2-Amino-3’,5’-di-O-acetyl-N6,N6-dimethyl-2’-O-methyladenosine is an adenosine analog, known for primarily acting as a smooth muscle vasodilator and for inhibiting cancer progression. Its popular products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

3’-Beta-C-Methyl-N6-isopentenyl adenosine, an adenosine analog, primarily acts as a smooth muscle vasodilator and has shown potential in inhibiting cancer progression. Popular products in this category include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].