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Dehydroaripiprazole

Catalog No. T10989 CAS 129722-25-4

Synonyms: OPC-14857, DM-14857

Dehydroaripiprazole (DM-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroaripiprazole. Dehydroaripiprazole has antipsychotic activity equivalent to aripiprazole.

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Dehydroaripiprazole, CAS 129722-25-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 247.00
50 mg	In stock	$ 368.00
100 mg	In stock	$ 543.00
500 mg	In stock	$ 1,160.00

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Purity: 97.05%

Biological Description

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Storage & Solubility Information

Description	Dehydroaripiprazole (DM-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroaripiprazole. Dehydroaripiprazole has antipsychotic activity equivalent to aripiprazole.
Targets&IC50	5-HT1A:4.2 nM (ki)

Synonyms	OPC-14857, DM-14857
Molecular Weight	446.37
Formula	C23H25Cl2N3O2
CAS No.	129722-25-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (24.65 mM)

References and Literature

1. Kirschbaum KM, et al. Serum levels of aripiprazole and dehydroaripiprazole, clinical response and side effects. World J Biol Psychiatry. 2008;9(3):212-8. 2. Lin SK, et al. Aripiprazole and dehydroaripiprazole plasma concentrations and clinical responses in patients with schizophrenia. J Clin Psychopharmacol. 2011 Dec;31(6):758-62. 3. Hui-ChingHuang, et al. Detection and quantification of aripiprazole and its metabolite, dehydroaripiprazole, by gas chromatography–mass spectrometry in blood samples of psychiatric patients. Journal of Chromatography B. Volume 856, Issues 1-2, 1 September 2007, Pages 57-61. 4. Stip E, Tourjman V. et al. Aripiprazole in schizophrenia and schizoaffective disorder: A review. Clin Ther. 2010;32 Suppl 1:S3-20.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Human Metabolite Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library Drug Metabolite/Impurity Library Neuronal Signaling Compound Library Serotonin Receptor-Targeted Compound Library

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Keywords

Dehydroaripiprazole 129722-25-4 GPCR/G Protein Neuroscience 5-HT Receptor inhibit antipsychotic CYP3A4 Inhibitor OPC-14857 Metabolite Serotonin Receptor DM14857 DM 14857 OPC14857 OPC 14857 5-hydroxytryptamine Receptor CYP2D6 DM-14857 inhibitor

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