Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
Description | Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. |
Targets&IC50 | Ovine COX-1:5.1 nM (IC50), Human COX-2:1.3 nM (IC50, in CHO cells), Ovine COX-2:0.84 nM (IC50), Human COX-1:4 nM (IC50, in CHO cells) |
In vitro | The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin. |
Synonyms | CGP-45840B, Cataflam, Voltfast, 双氯芬酸钾 |
Molecular Weight | 334.24 |
Formula | C14H10Cl2KNO2 |
CAS No. | 15307-81-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 10 mg/mL (29.91 mM)
Ethanol: <1 mg/mL
DMSO: 64 mg/mL (191.5 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Diclofenac Potassium 15307-81-0 凋亡 免疫与炎症 其他 神经科学 Apoptosis COX Others Voltfast CHO caspase COX-1 cascade anti-inflammatory neural cells stem ovine NSCs Diclofenac Inhibitor Cataflam inhibit CGP-45840B Cyclooxygenase COX-2 inhibitor