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Diclofenac Potassium

Catalog No. T6470 CAS 15307-81-0

Synonyms: CGP-45840B, Cataflam, Voltfast, 双氯芬酸钾

Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.

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Diclofenac Potassium, CAS 15307-81-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
Targets&IC50	Ovine COX-1:5.1 nM (IC50), Human COX-2:1.3 nM (IC50, in CHO cells), Ovine COX-2:0.84 nM (IC50), Human COX-1:4 nM (IC50, in CHO cells)
In vitro	The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

Synonyms	CGP-45840B, Cataflam, Voltfast, 双氯芬酸钾
Molecular Weight	334.24
Formula	C14H10Cl2KNO2
CAS No.	15307-81-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 10 mg/mL (29.91 mM)

Ethanol: <1 mg/mL

DMSO: 64 mg/mL (191.5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Dastidar SG, et al. Int J Antimicrob Agents, 2000, 14(3), 249-251. 2. Niethard FU, et al. J Rheumatol, 2005, 32(12), 2384-2392.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library Apoptosis Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Infection Compound Library

Related Products

Related compounds with same targets

(S)-(−)-Perillyl alcohol CPI-360 Diclofenac Potassium PF-543 GSK1904529A Ezatiostat LYN-1604 Curzerene

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Diclofenac Potassium 15307-81-0 凋亡免疫与炎症其他神经科学 Apoptosis COX Others Voltfast CHO caspase COX-1 cascade anti-inflammatory neural cells stem ovine NSCs Diclofenac Inhibitor Cataflam inhibit CGP-45840B Cyclooxygenase COX-2 inhibitor

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