Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 32.00 | |
10 mg | In stock | $ 52.00 | |
25 mg | In stock | $ 80.00 | |
50 mg | In stock | $ 107.00 | |
100 mg | In stock | $ 162.00 | |
200 mg | In stock | $ 226.00 | |
500 mg | In stock | $ 379.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia. |
In vitro | In healthy male rats, daily treatment with Dutasteride (100mg/kg) resulted in a prostate size that was half the size of that in control rats. |
In vivo | Dutasteride effectively inhibits Type I 5AR (IC50=6 nM) and Type II 5AR (IC50=7 nM). In LNCaP cells (IC50=1 μM), it suppresses DHT-induced PSA secretion and proliferation, and competes for androgen receptor (AR) binding (IC50=1.5 μM). Additionally, dutasteride reduces cell viability and proliferation in both androgen-responsive (LNCaP) and androgen-nonresponsive (DU145) human prostate cancer (PCa) cell lines. |
Synonyms | GG 745, Avodart, GI 198745 |
Molecular Weight | 528.53 |
Formula | C27H30F6N2O2 |
CAS No. | 164656-23-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 6 mg/mL (11.35 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 58 mg/mL (109.7 mM)
You can also refer to dose conversion for different animals. More
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Dutasteride 164656-23-9 Apoptosis Endocrinology/Hormones Metabolism Reductase GG 745 5 alpha Reductase Inhibitor inhibit Avodart GI-198745 GG745 5α-reductase GI198745 GI 198745 GG-745 inhibitor