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E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $47 | In Stock | |
5 mg | $105 | In Stock | |
10 mg | $178 | In Stock | |
25 mg | $297 | In Stock | |
50 mg | $455 | In Stock | |
100 mg | $655 | In Stock | |
1 mL x 10 mM (in DMSO) | $116 | In Stock |
Description | E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. |
In vitro | Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. [1]E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease. [4] |
In vivo | In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. [2] E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. [3] |
Alias | NSC 694279, Loxistatin Acid, EP 475 |
Molecular Weight | 314.38 |
Formula | C15H26N2O5 |
Cas No. | 76684-89-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 2 mg/mL (6.36 mM) DMSO: 58 mg/mL (184.5 mM) Ethanol: 58 mg/mL (184.5 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO/Ethanol
DMSO/Ethanol
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