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E 64c

Catalog No. T6573Cas No. 76684-89-4
Alias NSC 694279, Loxistatin Acid, EP 475

E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.

E 64c

E 64c

Purity: 99.9%
Catalog No. T6573Alias NSC 694279, Loxistatin Acid, EP 475Cas No. 76684-89-4
E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
Pack SizePriceAvailabilityQuantity
1 mg$47In Stock
5 mg$105In Stock
10 mg$178In Stock
25 mg$297In Stock
50 mg$455In Stock
100 mg$655In Stock
1 mL x 10 mM (in DMSO)$116In Stock
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Purity:99.9%
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Product Introduction

Bioactivity
Description
E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
In vitro
Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. [1]E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease. [4]
In vivo
In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. [2] E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. [3]
AliasNSC 694279, Loxistatin Acid, EP 475
Chemical Properties
Molecular Weight314.38
FormulaC15H26N2O5
Cas No.76684-89-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 2 mg/mL (6.36 mM)
DMSO: 58 mg/mL (184.5 mM)
Ethanol: 58 mg/mL (184.5 mM)
Solution Preparation Table
H2O/DMSO/Ethanol
1mg5mg10mg50mg
1 mM3.1809 mL15.9043 mL31.8086 mL159.0432 mL
5 mM0.6362 mL3.1809 mL6.3617 mL31.8086 mL
DMSO/Ethanol
1mg5mg10mg50mg
10 mM0.3181 mL1.5904 mL3.1809 mL15.9043 mL
20 mM0.1590 mL0.7952 mL1.5904 mL7.9522 mL
50 mM0.0636 mL0.3181 mL0.6362 mL3.1809 mL
100 mM0.0318 mL0.1590 mL0.3181 mL1.5904 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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