Home Tools
Log in
Cart

Emricasan

Catalog No. T6826   CAS 254750-02-2
Synonyms: PF 03491390, IDN-6556

Emricasan (IDN-6556) is an effective and irreversible pan-caspase inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Emricasan Chemical Structure
Emricasan, CAS 254750-02-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 37.00
2 mg In stock $ 53.00
5 mg In stock $ 87.00
10 mg In stock $ 147.00
25 mg In stock $ 267.00
50 mg In stock $ 441.00
100 mg In stock $ 649.00
1 mL * 10 mM (in DMSO) In stock $ 109.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.11%
Purity: 99%
Purity: 98.68%
Purity: 98.45%
Purity: 98.13%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Emricasan (IDN-6556) is an effective and irreversible pan-caspase inhibitor.
In vitro Emricasan (IDN-6556 or PF-03491390) is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan has a neuroprotective activity for hNPCs but does not inhibit ZIKV replication.
In vivo Emricasan reduces liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, Emricasan can attenuate stellate cell activation and hepatic fibrogenesis.
Cell Research Astrocytes are mock-infected, treated with DMSO or treated with 2 μM niclosamide, 92 μM PHA-690509, 9 μM emricasan, or a combination of 92 μM PHA-690509 and 9 μM emricasan for 1 h before infection with PRVABC59 (MOI = 0.5). Cells are fixed 24 h after infection and stained for ZIKVE and nuclei.(Only for Reference)
Synonyms PF 03491390, IDN-6556
Molecular Weight 569.5
Formula C26H27F4N3O7
CAS No. 254750-02-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (163.3 mM)

Ethanol: 93 mg/mL (163.3 mM)

TargetMolReferences and Literature

1. Barreyro FJ, et al. Liver Int. 2015, 35(3):953-66. 2. Xu M, et al. Nat Med. 2016, [Epub ahead of print]. 3. Tang Q, Li W, Zheng X, et al. MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma[J]. Signal Transduction and Targeted Therapy. 2020, 5(1): 1-12. 4. Tang Q, Ren L, Liu J, et al. Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4‐ATF3‐CHOP axis[J]. Cell proliferation. 2019: e12706.

TargetMolCitations

1. Tang Q, Li W, Zheng X, et al. MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma. Signal Transduction and Targeted Therapy. 2020, 5(1): 1-12. 2. Tang Q, Ren L, Liu J, et al. Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4‐ATF3‐CHOP axis. Cell proliferation. 2019: e12706 3. Zhou R, You Y, Zha Z, et al.Biotin decorated celastrol-loaded ZIF-8 nano-drug delivery system targeted epithelial ovarian cancer therapy.Biomedicine & Pharmacotherapy.2023, 167: 115573. 4. Li J, Han X, Sun M, et al.Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity.Journal for Immunotherapy of Cancer.2023, 11(12). 5. Chen J, Liu Y, You Y, et al.Biotin-decorated celastrol-loaded ZIF-8 nanoparticles induce ferroptosis for colorectal cancer therapy.Materials & Design.2024: 112814.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Highly Selective Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Target-Focused Phenotypic Screening Library NO PAINS Compound Library Inhibitor Library Anti-Hypertension Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets
Anti-Influenza agent 4 Umifenovir hydrochloride Oseltamivir phosphate RdRP-IN-5 Baloxavir marboxil kaempferide Iniparib Tyrphostin A9

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Emricasan 254750-02-2 Apoptosis Microbiology/Virology Proteases/Proteasome Caspase Influenza Virus Inhibitor IDN 6556 PF-03491390 IDN6556 PF03491390 inhibit PF 03491390 IDN-6556 inhibitor

 

TargetMol