Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Emricasan (IDN-6556) is an effective and irreversible pan-caspase inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 37.00 | |
2 mg | In stock | $ 53.00 | |
5 mg | In stock | $ 87.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 267.00 | |
50 mg | In stock | $ 441.00 | |
100 mg | In stock | $ 649.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 109.00 |
Description | Emricasan (IDN-6556) is an effective and irreversible pan-caspase inhibitor. |
In vitro | Emricasan (IDN-6556 or PF-03491390) is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan has a neuroprotective activity for hNPCs but does not inhibit ZIKV replication. |
In vivo | Emricasan reduces liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, Emricasan can attenuate stellate cell activation and hepatic fibrogenesis. |
Cell Research | Astrocytes are mock-infected, treated with DMSO or treated with 2 μM niclosamide, 92 μM PHA-690509, 9 μM emricasan, or a combination of 92 μM PHA-690509 and 9 μM emricasan for 1 h before infection with PRVABC59 (MOI = 0.5). Cells are fixed 24 h after infection and stained for ZIKVE and nuclei.(Only for Reference) |
Synonyms | PF 03491390, IDN-6556 |
Molecular Weight | 569.5 |
Formula | C26H27F4N3O7 |
CAS No. | 254750-02-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (163.3 mM)
Ethanol: 93 mg/mL (163.3 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Emricasan 254750-02-2 Apoptosis Microbiology/Virology Proteases/Proteasome Caspase Influenza Virus Inhibitor IDN 6556 PF-03491390 IDN6556 PF03491390 inhibit PF 03491390 IDN-6556 inhibitor